| Loss Of Heterozygosity |
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Loss of heterozygosity can arise by two methods. In the first, a region of a Chromosome is deleted, resulting in only one copy remaining. In the second, Genetic Recombination leaves the cell with two copies of the chromosomal region, but both come from the same parent. Loss of heterozygosity can be identified in cancers by noting the presence of Heterozygosity at a genetic Locus in an organism's Germline DNA , and the absence of heterozygosity at that locus in the cancer cells. This is often done using Polymorphic markers, such as Microsatellites or Single Nucleotide Polymorphisms , for which the two parents contributed different Alleles . SEE ALSO Tumor Suppressor Gene |
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