| Loss-of-function Mutation |
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Information AboutLoss-of-function Mutation |
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A loss-of-function mutation can for instance be caused by the truncation of the gene product because of a Frameshift or Nonsense Mutation . Often an organism will function normally with a loss-of-function mutation in an allele, so long as there is at least one functioning Allele of the gene in question. If this is the case, then the phenotype associated with the mutated allele will be Recessive . Examples of this are the alleles responsible for Sickle Cell Anemia and Cystic Fibrosis . On the other hand, if the dosage of gene product supplied by the remaining normal alleles is not enough for normal function of the organism because of Haploinsufficiency , then the associated phenotype will be Dominant . |
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