Letterer-siwe Disease Website Links For
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Letterer-siwe Disease




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Letterer-Siwe disease is a condition where Histiocytes proliferate in the body. It is sometimes classified as a form of Langerhans Cell Histiocytosis , or as a diseminated form of Histiocytosis X . It is most commonly seen in children less than two years old.

Symptoms include Lymphadenopathy , Hepatosplenomegaly , and Seborrhea -like lesions on the skin. Untreated, the disease is fatal. The five-year survival rate with treatment is fifty percent.


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