- Alan Knight , former English footballer
- Albert Knight , English professional cricket player
- Albion Knight, Jr. , American politician and Anglican bishop
- Andrew Knight , English journalist, editor, and media magnate
- Anne Knight , British-born author, social reformer and pioneer of feminism
- Arabella Knight , English erotic writer
- Barry Knight , former English cricketer
- Beverley Knight , English R&B artist
- Bobby Knight , American NCAA basketball coach
- Brevin Knight , American NBA basketball player
- Charles Knight , English publisher and author
- Charles Landon Knight , American lawyer and newspaper publisher
- Christopher Knight , American actor
- Christopher Knight , ezine publisher and email deliverablilty expert
- Crystal Knight , American erotic actress and exotic dancer
- Curtis Knight , British musical artist and band leader
- Damon Knight , American science-fiction author, editor, and critic
- Dennis Knight , American professional wrestler
- Dick Knight , British advertising executive
- Don Knight , former Canadian politician
- Donald Knight , English cricketer
- Douglas Knight , American businessman, educator and author
- Eric Knight , English author and the creator of the fictional collie ''Lassie''
- Esmond Knight , British character actor
- Etheridge Knight , African-American poet
- Frank Knight , American economist
- Gareth Knight , British esotericist and author
- Gladys Knight , American R&B/soul singer and actress
- Goodwin Knight , US politician and 31st California governor
- Greg Knight , British politician and MP
- G. Wilson Knight , English literary critic and academic
- Holly Knight , American songwriter, vocalist and musician
- James Knight , British explorer
- Jason Knight , American professional wrestler and manager
- Jean Knight , African-American soul/R&B/funk singer
- Jerry Knight , American R&B musician
- Jill Knight , British MP
- Jim Knight , British politician
- John S. Knight , American editor and newspaper publisher
- Jonathan Knight , American pop singer
- Jonathan Knight (1787-1858), early American railroad construction engineer
- Jordan Knight , American pop singer
- Joseph Knight , Jamaican slave who was the defendant in a historic Scottish civil rights trial
- Julian Knight , Australian serial killer
- Keith Knight , American cartoonist and musician
- Keith Knight , British professional soccer player
- Leon Knight , English professional soccer player
- Leonard Knight , American builder and architect
- Margaret Knight , American inventor of the paper-bag-making machine
- Margaret Knight , humanist broadcaster and university lecturer
- Mark Knight , American Amiga demoscene musician and video game composer/sound designer
- Merald "Bubba" Knight , American R&B/soul singer
- Nick Knight , English cricket player
- Nick Knight , British photographer
- Pedro Knight , Cuban musician and the husband of Celia Cruz
- Phil Knight , American businessman, co-founder and ex-CEO of Nike
- Phil Knight ,New Zealand musician
- Ray Knight , American former major league baseball player
- Robert Knight , Australian politician
- Roger Knight , English cricketer, administrator, and schoolmaster
- Rosalind Knight , British actress
- Ross Knight , Australian physician
- Peter Knight , British folk musician
- Samuel Knight , English clergyman and antiquary
- Sammy Knight , American NFL football player
- Shirley Knight , American actress
- Stephen Knight , British author
- Suge Knight , US hop hop music industry entrepreneur
- Ted Knight , American actor
- Terry Knight , American rock music producer, promoter, singer, songwriter and radio personality
- Tom Knight , research scientist at MIT
- Tonya Knight , US professional female body builder
- Tuesday Knight , American actress
- Victoria Knight , ''Playboy'' model
- Wayne Knight , American actor
- Wilfried Knight , European pornographic actor
- William Knight , member of the court of Henry VIII
- Captain William Knight , English buccaneer
- William J. Knight , X-15 pilot and United States politician
- William Knight , Venerable William Knight, martyred in 1596
- Wyatt Knight , American actor
- Zat Knight , English professional soccer player
- Garthe Knight, fictional character from the TV series '' Knight Rider
- Michael Knight, the protagonist of the TV series '' Knight Rider
- Red Knight , title borne by several characters in Arthurian legend
- Knight , English term for the European social position of lowest aristocratic rank
- Knight , one of the pieces in the game of chess
- Knight Library , main library of the University of Oregon in Eugene, Oregon
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