Information AboutIn Vivo |
| CATEGORIES ABOUT IN VIVO | |
| latin biological phrases | |
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''In vivo'' research differentiates whole organism research from '' In Vitro '' research, which is performed on Organs , Tissues , Cells , cellular components, Proteins , or Biomolecules . ''In vivo'' can also refer to a medical context, such as ''in vivo'' Fertilisation (c.f. ''in Vitro'' Fertilisation ). ''IN VIVO'' RESEARCH ''In vivo'' research is more suited to observe an overall effect than ''in vitro'' research, which is better suited to deduce mechanisms of action. ''In vitro'' research aims to describe and understand the effect of an experimental variable on a subset of an organism's components. ''In vitro'' research has the advantage over ''in vivo'' research that there are fewer variables which can confound an experiment, and that if an experimental effect is subtle the result will be more clearly visible. ''In vivo'' research has the advantage, ''Whether the aim is to discover drugs or to gain knowledge of biological systems, the nature and properties of a chemical tool cannot be considered independently of the system it is to be tested in. Compounds that bind to isolated recombinant proteins are one thing; chemical tools that can perturb cell function another; and pharmacological agents that can be tolerated by a live organism and perturb its systems are yet another. If it were simple to ascertain the properties required to develop a lead discovered in vitro to one that is active in vivo, drug discovery would be as reliable as drug manufacturing.''1}} The massive adoption of low-cost, ''in vitro'', Molecular Biology techniques has caused a move away from ''in vivo'' research, which is considered too idiosyncratic and, above all, expensive compared to its molecular counterpart. Currently, ''in vitro'' models and experiments are a vital and highly productive research tool. The s and mice. As the term is in Latin, it is written in italics. SEE ALSO REFERENCES |
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