| Human Chorionic Gonadotropin |
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| CATEGORIES ABOUT HUMAN CHORIONIC GONADOTROPIN | |
| glycoproteins | |
| peptide hormones | |
| gonadotropic hormones | |
| placental hormones | |
| chemical pathology | |
| tumor markers | |
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STRUCTURE hCG is a Glycoprotein composed of 244 Amino Acid s with a Molecular Mass of 36.7 KDa . It is Heterodimer ic, with an α (alpha) Subunit identical to that of Luteinizing Hormone (LH), Follicle-stimulating Hormone (FSH), and Thyroid-stimulating Hormone (TSH) and β (beta) subunit that is unique to hCG. βhCG is encoded by six highly homologous Gene s which are arranged in tandem and inverted pairs on Chromosome 19 q13.3 - ''CGB''( ''1'' , ''2'' , ''3'' , ''5'' , ''7'' , ''8'' ). FUNCTION hCG promotes the maintenance of the Corpus Luteum and causes it to secrete the hormone Progesterone . Progesterone enriches the Uterus with a thick Lining of Blood Vessel s and Capillaries so that it can sustain the growing Fetus . Because of its similarity to LH , hCG can also be used clinically to induce Ovulation in the Ovaries as well as Testosterone production in the Testes . As the most abundant biological source is women who are presently pregnant, some organizations collect urine from Gravida e to extract hCG for use in Fertility Treatment . PREGNANCY TESTING Pregnancy Test s measure the levels of hCG in the Blood or Urine to indicate the presence or absence of an implanted Embryo . In particular, most pregnancy tests employ an Antibody that is specific to the β-subunit of hCG (βhCG). This is important so that tests do not make False Positive s by confusing hCG with LH and FSH. (The latter two are always present at varying levels in the body, while hCG levels are negligible except during pregnancy.) The urine test is a chromatographic Immunoassay that can detect levels of βhCG as low as 25-100 mIU/ml. The urine should be the first urine of the morning when hCG levels are highest. If the Specific Gravity of the urine is above 1.015, the urine should be diluted. The Serum test, using 2-4 mL of venous blood, is a Radioimmunoassay (RIA) that can detect βhCG levels as low as 5 mIU/ml and allows quantitation of the βhCG concentration. The ability to quantitate the βhCG level is useful in the evaluation of Ectopic Pregnancy and in monitoring Germ Cell and Trophoblastic Tumor s. Hydatiform Mole s ("molar pregnancy") may produce high levels of βhCG, despite the absence of an embryo. This can lead to false positive readings of pregnancy tests. TUMOR MARKER βhCG is also secreted by some Cancer s including Teratoma s, Choriocarcinoma s and Islet Cell Tumor s. When a patient is suspected of harboring a teratoma (often found in the Testes and Ovaries but also in the Brain as a Dysgerminoma ), a physician may consider measuring βhCG. Elevated levels cannot prove the presence of a tumor, and low levels do not rule it out (an exception is in males who do not naturally produce βhCG). Nevertheless, elevated βhCG levels fall after successful treatment (e.g. surgical intervention or Chemotherapy ), and a recurrence can often be detected by the finding of rising levels. USE AS MEDICATION hCG is extensively used as a Parenteral medication in fertility therapy in lieu of Luteinizing Hormone . In the presence of one or more mature ovarian follicles, ovulation can be triggered by the administration of hCG. As Ovulation will happen about 40-45 hours after the injection of hCG, procedures can be scheduled to take advantage of this time sequence. Thus, patients who undergo IVF , typically receive hCG to trigger the ovulation process, but have their eggs retrieved at about 36 hours after injection, a few hours before the eggs actually would be released from the ovary. As hCG supports the Corpus Luteum , administration of hCG is also used in certain circumstances to enhances the its Progesterone production. In the male, hCG injections are used to stimulate the Leydig Cell s to synthesize Testosterone . The intratesticular testosterone is necessary for Spermatogenesis from the Sertoli Cells . Typical indications for hCG in men include Hypogonadism and fertility treatment. hCG sold under brand names including Pregnyl®, Follutein®, Profasi®, and Novarel® use chorionic gonadotropins derived form the urine of pregnant women, while Ovidrel® is a product of recombinant technology. Novarel® and hCG from APP are typically considered generics in the United States . RECREATIONAL USE WITH STEROIDS In the world of performance enhancing drugs, hCG is increasingly used in combination with various Anabolic Androgenic Steroid (AAS) cycles. When AAS are put into a male body, the body's natural negative feedback loops cause the body to shut down its own production of Testosterone via shutdown of the HPTA (hypothalamic-pituitary-testicular axis). High levels of AASs that mimic the body's natural testosterone trigger the Hypothalamus to shut down its production of Gonadotropin-releasing Hormone (GnRH) from the hypothalamus. Without GnRH the Pituitary Gland stops releasing Luteinizing Hormone (LH). LH normally travels from the pituitary via the blood stream to the Testes where it triggers the production and release of testosterone. Without LH, the testes shut down their production of testosterone, causing testicular atrophy ("shrinking testicles"). In males, hCG mimics LH and helps restore / maintain testosterone production in the testes. As such, hCG is commonly used during and after steroid cycles to maintain and restore testicular size as well as endogenous testosterone production. |
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