| Gene Conversion |
Article Index for Gene |
Website Links For Gene |
Information AboutGene Conversion |
| CATEGORIES ABOUT GENE CONVERSION | |
| genetics | |
|
Gene conversion is a phenomenon which occurs during Meiotic division. It is a process by which DNA sequence information is transferred from one DNA helix (which remains unchanged) to another DNA helix, whose sequence is altered. It occurs occasionally during general Recombination . Meiosis is the cell division step that produces the . The strands then segregate, over two cell division steps, into four Haploid daughter cells - with half the amount of genetic material each as the original mother cell. If you have a gene at which an organism inherited different copies from each of its parents, it is called heterozygous: generically represented as genotype: Aa (i.e. one copy of variant ( Allele ) 'A', and one copy of allele 'a'). When a heterozygote creates gametes, the alleles should split, and end up in a 1:1 ratio in the resulting cells. However, gene conversion refers to an error during meiosis, in which a ratio other than the expected 1A:1a is observed - for example 3A:1a, 1A:3a, 5A:3a or 3A:5a. This conversion of one allele to the other is due to inappropriate base mismatch repair during recombination: if one of the four strands during meiosis pairs up with one of the four strands of a different Chromosome , as can occur if there is sequence Homology , mismatch repair can alter the sequence of one of the chromosomes, to match identically that on the other. Also is one of the ways a gene may be mutated to create a cancerous gene. |
|
|