| Factor Viii |
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Information AboutFactor Viii |
| CATEGORIES ABOUT FACTOR VIII | |
| acute phase proteins | |
| recombinant proteins | |
| coagulation system | |
| genes associated with genetic disorders | |
| cofactors | |
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GENETICS The gene for Factor VIII is located on the X Chromosome (Xq28). PHYSIOLOGY FVIII is a Glycoprotein pro Cofactor synthesized and released into the bloodstream by the Liver . In the circulating blood, it is mainly bound to Von Willebrand Factor (vWF, also known as ''Factor VIII-related antigen'') to form a stable complex. Upon activation by Thrombin or Factor X a, it dissociates from the complex to interact with Factor IX a the Coagulation Cascade . It is a cofactor to Factor IX a in the activation of Factor X , which, in turn, with its cofactor Factor V a, activates more thrombin. Thrombin cleaves Fibrin ogen into Fibrin which Polymer izes and crosslinks (using Factor XIII ) into a blood clot. No longer protected by vWF, activated FVIII is Proteolytically inactivated in the process (most prominently by activated Protein C and Factor IX a) and quickly cleared from the blood stream. THERAPEUTIC USE FVIII harvested from donated blood (or more likely, purchased blood plasma) or Recombinant FVIII can be given to Hemophiliac s to restore Hemostasis . Thus, FVIII is also known as ''Anti''-Hemophilic Factor. This transfer of a Plasma biproduct into the blood stream of a Hemophiliac often lead to the transmission of diseases such as HIV and Hepatitis . In the early 1990s, pharmaceutical companies began to produce synthesized factor products, which now prevent nearly all forms of disease transmission during replacement therapy. |
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