Information AboutFactor Ix |
| CATEGORIES ABOUT FACTOR IX | |
| coagulation system | |
| ec 3.4.21 | |
| genes associated with genetic disorders | |
| peripheral membrane proteins | |
|
PHYSIOLOGY Factor IX is inactive unless activated by Factor XI a (of the contact pathway) or Factor VII a (of the tissue factor pathway). When activated into factor IXa, it acts by hydrolysing one Arginine - Isoleucine bond in Factor X to form factor Xa. It requires Calcium , membrane Phospholipid s, and Factor VIII as Cofactor s to do so. GENETICS The Gene for factor IX is located on the X Chromosome (Xq27.1-q27.2). ROLE IN DISEASE Deficiency of factor IX causes Christmas disease ( Hemophilia B ). Over 100 mutations of factor IX have been described; some cause no symptoms, but many lead to a significant bleeding disorder. EXTERNAL LINK |
|
|