- Aaron Douglas (1900–1979), American artist, major figure in the Harlem Renaissance
- Alec Douglas-Home (1903–1995), British Baron , politician, Prime Minister (1963–1964)
- Andy Douglas (contemporary), American Professional Wrestler
- Aretas Akers-Douglas , 1st Viscount Chilston (1851–1926), British statesman and politician
- Ashanti (singer) (Ashanti Shaquoya Douglas) (1980–), American R&B singer
- Bobby Douglass (born 1947), NFL quarterback from 1969 to 1978
- C. H. Douglas (1879–1952), Scottish engineer and pioneer of the Social Credit concept
- Campbell Mellis Douglas (1841– {Link without Title} ), Canadian recipient of the Victoria Cross
- Carl Douglas , Jamaican -born singer
- Charles R Douglas (1989 - ), Scottish, Amateur Tennis Player
- Donald Wills Douglas, Sr. (1892–1981), American aircraft industrialist, founder of the Douglas Aircraft Company
- Lord Alfred Douglas (1870–1945), nicknamed "Bosie", British poet, third son of John Sholto Douglas , 9th Marquess of Queensberry; partner of Oscar Wilde
- David Douglas (1799–1834), Scottish botanist, Eponym of the Douglas Fir tree
- Denzil Douglas (1953–), Prime Minister of St Kitts And Nevis
- Douglas "Doug" Christie (contemporary), Canadian lawyer and political activist
- Frederick Douglass (1818–1895), American Abolitionist , editor, orator, author, statesman, and reformer.
- Gavin Douglas (1474–1522), Scottish Poet and Bishop
- Gordon Douglas (1907–1993), American Actor and Director
- Gustaf Douglas (1938–) Swedish businessman, vice chairman and largest single shareholder in security firm Securitas AB
- Hal Douglas (contemporary), voice actor
- Helen Gahagan (Douglas) a.k.a. ''The Pink Lady'' (1900–1980), American actress and politician, Representative from California , coined the nickname ''Tricky Dick'' for Richard Nixon ; grandmother of Illeana Douglas
- Hugh Douglas (1971–), American NFL Football player
- Illeana Douglas (1965–), American actress
- James Douglas a.k.a ''The Good'', ''The Black Douglas'' (1286–1330), Scottish soldier and knight in the Scottish Wars Of Independence
- James Douglas (1675–1742), Scottish physician and Anatomist , and physician to the Queen.
- James Douglas (1803–1877), Scottish-Canadian governor of the colony of Vancouver Island 1851–1864
- James "Buster" Douglas (1960–), American heavyweight boxer, knocked out Mike Tyson in 1990
- Jerry Douglas (1955–), American Country Music and Bluegrass musician
- Jesse Douglas (1897–1965), American Mathematician and Professor of Mathematics
- Jim Douglas (1952–), American politician, governor of Vermont As Of 2005
- John Douglas (1721–1807), Scottish man of letters and Anglican bishop
- Katie Douglas (1979–), American Women's National Basketball Association (WNBA) player
- Keith Douglas (1920–1944), English Poet of World War II
- Kirk Douglas (1916–), American actor, father of Michael Douglas
- Kyan Douglas (1970–), American Cosmetologist
- Marjory Stoneman Douglas (1890–1998), American Conservationist and writer: ''The Everglades: River of Grass'' (1947)
- Mark Douglas-Home (contemporary), Scottish editor-in-chief of ''The Herald'' in Glasgow, Scotland, nephew of Alec Douglas-Home
- Mary Douglas (1921- ) Britisch Anthropologist
- Melvyn Douglas (1901–1981), American Actor : ''The Americanization of Emily'', ''Hud''
- Michael Douglas (1944–), American Actor and Producer , son of Kirk Douglas
- Michael Douglas (1945–1963), 17-year-old acquaintance of First Lady Laura Bush (then Laura Welch) who was killed in a traffic collision caused by Welch
- Michael Douglas, real name of American actor Michael Keaton
- Michael Douglas, shared Pseudonym of American author Michael Crichton and his brother Douglas
- Michael R. Douglas , (contemporary), American Physicist at Rutgers University
- Mike Douglas , (1925–), American entertainer and former TV Talk-show host
- Norman Douglas (1868–1952), British writer: ''South Wind'' (1917)
- Paul Douglas (1907–1959), American Actor
- Paul Douglas (1892–1976), American economist and United States Senator from Illinois 1949 –1967
- Roger Douglas (1973–), former New Zealand politician, founder of the Association Of Consumers And Taxpayers (ACT)
- Rosie Douglas , (1941–2000), Dominican politician, Prime Minister of Dominica 2000
- Sarah Douglas (1952–), English actress
- Shane Douglas a.k.a. ''The Franchise'' (1964–), American professional wrestler
- Shirley Douglas (1934–), Canadian actress, former wife of Donald Sutherland and mother of Kiefer Sutherland
- Stephen A. Douglas (1813–1861), American politician, candidate for President in 1860 , lost to Abraham Lincoln
- Tommy Douglas (1904–1986), Canadian politician, Premier of Saskatchewan 1944 – 1961 , father of Shirley Douglas
- William Lewis Douglas (1845–1924), American politician, Governor of Massachusetts 1905 – 1906
- William O. Douglas (1898–1980), American Associate Justice of the Supreme Court
- Archibald Douglas, 5th Earl Of Angus (1450–1514)
- Archibald Douglas, 8th Earl Of Angus (1555–1588)
- James Douglas, 2nd Earl Of Douglas (1358–1388)
- James Douglas, 4th Earl Of Morton (c. 1525–1581)
- James Douglas, 4th Duke Of Hamilton (1658–1712)
- John Douglas, 2nd Earl Of Morton (d.1513)
- John Sholto Douglas, 9th Marquess Of Queensberry (1844–1900)
- Margaret Douglas , Countess of Lennox (1515–1578)
- Thomas Douglas, 5th Earl Of Selkirk (1771–1820)
- William Douglas, 1st Duke Of Queensberry (1637–1695)
- William Douglas, 10th Earl Of Angus ( 1553–1611)
- Douglas , the Capital of the Isle Of Man
- Camp Douglas , Juneau County , Wisconsin , USA
- Castle Douglas , town in Dumfries And Galloway , Scotland
- Douglas , neighborhood located on the south side of Chicago , Illinois
- Douglas , Cochise County , Arizona , USA
- Douglas , Marshall County , Alabama , USA
- Douglas , Coffee County , Georgia , USA
- Douglas , Massachusetts ,USA
- Douglas , Allegan County , Michigan , USA
- Douglas Township , Dakota County , Minnesota , USA
- Douglas , Otoe County , Nebraska , USA
- Douglas , Ward County , North Dakota , USA
- Douglas , Garfield County , Oklahoma ,USA
- Douglas, Scotland , village near Lanark
- Douglas , Marquette County , Wisconsin , USA
- Douglas , Converse County , Wyoming , USA
- East Douglas , Worcester County , Massachusetts , USA
- New Douglas , Madison County , Illinois , USA
- Port Douglas , coastal Resort town in Queensland , Australia
- Douglas , suburb of Cork , Ireland
- Douglas , Dundee , Scotland
- Douglas County, Colorado , USA
- Douglas County, Georgia , USA
- Douglas County, Illinois , USA
- Douglas County, Kansas , USA
- Douglas County, Minnesota , USA
- Douglas County, Missouri , USA
- Douglas County, Nebraska , USA
- Douglas County, Nevada , USA
- Douglas County, Oregon , USA
- Douglas County, South Dakota , USA
- Douglas County, Washington , USA
- Douglas County, Wisconsin , USA
- Douglas AG
- Brewster-Douglas , public housing project located in Detroit , Michigan
- Burnaby—Douglas , Canadian federal electoral district in British Columbia
- Camp Douglas , Union Prisoner Of War camp during the American Civil War
- The Cobb-Douglas functional form of production functions in economics
- Charlotte Douglas International Airport , Charlotte , North Carolina
- Douglas Aircraft Company , American aircraft manufacturer (1921–1967), founded by Donald Wills Douglas, Sr. 1921, followin
- Various aircraft manufactured by
- Douglas Fir , a Coniferous tree of the genus ''Pseudotsuga''
- Douglas Hyde Gallery , Art Gallery at Trinity College , Dublin , Ireland
- Douglas Squirrel , a squirrel of the species ''Tamiasciurus douglasii''
- Douglas Apsley National Park in Tasmania, Australia
- McDonnell Douglas , American aerospace company, (1967–1997)
- Various aircraft manufactured by McDonnell Douglas: see List Of Aircraft (I-M)#McDonnell
- House Of Douglas , Scottish Noble house
- Fort Douglas , fort of the Hudson Bay Company , built in 1812, now near Winnipeg , Manitoba
- Fort Douglas , U.S. Army fort established in Utah Territory
- Point Douglas , historical community and provincial electoral division in the Canadian Province of Manitoba
- Pouch Of Douglas , extension of the Peritoneal cavity between the Rectum and back wall of the Uterus in the Female Human Body
- Regina Douglas Park , provincial electoral district for the Legislative Assembly of Saskatchewan , Canada
- USS Douglas H. Fox (DD-779) (1944–1973), ''Allen M. Sumner'' class destroyer
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