- Adam Curtis
- Benjamin Robbins Curtis (1809-1874), American jurist
- Ben Curtis (golfer) (1978- ), American golfer
- Ben Curtis (actor) (1980- ), American actor
- Charles Curtis (1860-1936), US Vice President
- Charles Curtiss (1908 - 1993), American Communist
- Cyrus Hermann Kotzschmar Curtis
- Edward S. Curtis (1868 – 1952) the photographer
- George Ticknor Curtis
- George William Curtis
- Glenn Curtiss Aviation pioneer and founder of the Curtiss Aeroplane and Motor Company
- Heber Doust Curtis (1872–1942), American astronomer
- Ian Curtis (1956-1980), British singer-songwriter
- Jamie Lee Curtis , Actress
- John Curtis (entomologist) (1791-1862), English entomologist
- John Curtis (orientalist) , British Museum orientalist
- Kelly Curtis , Actress
- King Curtis
- Marry Louise Curtis , thefounder of the Curtis Institute Of Music , Philadelphia
- Richard Curtis , British comedy scriptwriter
- Philip Kenneth Edward Curtis
- Tony Curtis
- William Curtis (1746-1799), English botanist
- Rey Curtis , a fictional character on ''Law & Order''.
- Izumi Curtis , a fictional character in Fullmetal Alchemist
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