is a malignant and aggressive
Cancer of the
Placenta . It is characterized by '''early hematogenous spread''' to the lungs.
It is
On
Light Microscopy , there is malignant
Trophoblast ic proliferation without hydropic villi.
Choriocarcinoma is one of the tumors that is most sensitive to chemotherapy. The cure rate, even for metastatic choriocarcinoma, is around 90-95%. Virtually everyone without metastases can be cured. Chemotherapy regimen include
Methotrexate or
Dactinomycin .
Hysterectomy (surgical removal of the uterus) can also be offered to patients > 40 years of age or those desiring sterilization. It may be required for those with severe infection and uncontrolled bleeding.
