| Calcitonin |
Website Links For Calcitonin |
Information AboutCalcitonin |
| CATEGORIES ABOUT CALCITONIN | |
| peptide hormones | |
| hormones of the thyroid gland | |
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in Human s primarily by the C cells of the Thyroid , and in many other animals in the Ultimobranchial Body . SYNTHESIS It is formed by Proteolytic cleavage of a larger prepropeptide which is the product of the ''CALC1'' gene, which itself is part of a superfamily of related protein hormone precusors including Islet Amyloid Precursor Protein, Calcitonin Gene-Related Peptide and the precursor of Adrenomedullin. PHYSIOLOGY The hormone participates in Calcium and Phosphorus Metabolism and it was found in fish, reptiles, birds and mammals. Most evidence indicates that calcitonin is of very little physiological importance to humans. Rather, calcium and phosphate homeostasis is primarily under the control of Parathyroid Hormone (PTH). Specifically, calcitonin reduces blood Calcium levels in three ways:
Its actions, broadly, are:
Like the PTH receptor, the receptor of calcitonin is a serpentine G Protein -coupled receptor with seven membrane spanning regions which is coupled by Gs to Adenylyl Cyclase and thereby to the generation of CAMP in target cells. Indeed, the PTH and calcitonin receptors are family members which are related in amino acid sequence, though their ligands are not. PHARMACOLOGY Salmon calcitonin is used for the treatment of:
HISTORY Calcitonin was purified in 1962 by Copp and Cheney. While it was initially considered a secretion of the Parathyroid Gland s, it was later identified as the secretion of the C-cells (parafollicular cells) of the thyroid. SEE ALSO REFERENCE
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