| Brosylate |
Articles about Tosyl |
Information AboutBrosylate |
| CATEGORIES ABOUT TOSYL | |
| functional groups | |
| leaving group | |
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A tosyl group (abbreviated '''Ts''') combines the Toluene and Sulfonyl Functional Groups . A Sulfonyl group consists of a hexavalent Sulfur Atom Double Bond ed to two Oxygen atoms and an Aromatic Ring ; an Alkyl substitutent on the R group forms a ''' Sulfonate ester'''. Thus, the '''tosylate''' group is the ester of toluene Sulfonic Acid . The Para Orientation illustrated ('''p-toluenesulfonyl''') is most common, and by convention tosyl refers to the p-toluenesulfonate ester. A tosylate ester has only a limited shelf life if it is stored outside of a desicator as the free tosyl is readily broken by light and water. The tosyl group is Electron-withdrawing . The tosyl group is a Protecting Group for Alcohol s, prepared by combining the alcohol with Toluenesulfonyl Chloride in an Aprotic Solvent . Toluenesulfonyl chlorides activate alcohols for Nucleophilic Attack or Elimination (dehydration). Similarly, the brosyl ('''Bs''') group or '''brosylate''' is a p-bromobenzenesulfonyl group with the methyl group of toluene replaced by a Bromine atom. '''Nosyl''' groups in '''Nosylates''' ('''Ns''') are 2-nitrobenzenesulfonyl groups with a Nitro group in the Ortho position. |
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