Information AboutBicuculline |
| CATEGORIES ABOUT BICUCULLINE | |
| gaba antagonists | |
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The action of bicuculline is primarily on the Ionotropic GABA A receptor, which is a ligand-gated Ion channel concerned chiefly with the passing of chloride ions across the cell membrane, thus promoting an inhibitory influence on the target Neuron . This receptor is the major target for Benzodiazepines and related Anxiolytic drugs. Sensitivity to bicuculline is defined by IUPHAR as a major criterion in the definition of GABAA receptors - however in recent years a new class of ionotropic GABA receptor, defined variously as GABAA0R or GABAC has been characterised, which is insensitive to both benzodiazepines and bicuculline. |
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