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Beta-lactamase




The structure of a '' Streptomyces '' β lactamase is given by .


PENICILLINASE


Penicillinase is a particular type of β lactamase, showing specificity for Penicillin s again by Hydrolysing the Beta-lactam ring. Molecular weights of the various penicillinases tend to cluster near 50,000.

Penicillinase was the first β lactamase to emerge, due to the early dependence on penicillin. Penicillinase resistant β lactams were then developed such as Methicillin , although there is widespread Resistance to these now also (see MRSA ).


REFERENCE

  • Jacoby GA, Munoz-Price LS. ''The new β-lactamases''. N Engl J Med 2005;352:380-91. PMID 15673804

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