| Autocrine |
Website Links For Signalling |
Information AboutAutocrine |
| CATEGORIES ABOUT AUTOCRINE SIGNALLING | |
| signal transduction | |
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An example of an autocrine agent is the Cytokine Interleukin-1 in Monocytes . When this is produced in response to external stimuli, it can bind to cell-surface Receptors on the same cell that produced it. Another example occurs in activated costimulatory signal. Upon activation, "low affinity" IL-2 receptors are replaced by "high affinity" IL-2 receptors consisting of α, β, and γ chains. The cell then releases IL-2 which binds to its own new IL-2 receptors, causing self-stimulation and ultimately a Monoclonal population of T cells. These T cells can then go on to perform effector functions such as Macrophage activation, B Cell activation, and cell-mediated Cytoxicity . SEE ALSO |
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