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NOYES-WHITNEY EQUATION


Along with Willis Rodney Whitney , he formulated the Noyes-Whitney Equation in 1897 , which relates the Rate of Dissolution of Solid s to the properties of the solid and the dissolution Medium . It is an important equation in Pharmaceutical Science . The relation is given by:

: rac{dW}{dt} = rac{DA(C_{s}-C)}{L}

Where:
  • rac{dW}{dt} is the rate of dissolution.

  • A is the Surface Area of the solid.

  • C is the concentration of the solid in the bulk dissolution medium.

  • C_{s} is the concentration of the solid in the Diffusion layer surrounding the solid.

  • D is the diffusion Coefficient .

  • L is the Diffusion Layer thickness.




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