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In the first sense referred to above, an amide is essentially an O ) N R2R3 where either or both of R2 and R3 may be Hydrogen . Specifically, an amide can also be regarded as a derivative of a Carboxylic Acid in which the hydroxyl group has been replaced by an Amine or Ammonia . Compounds in which a Hydrogen atom on nitrogen from Ammonia or an Amine is replaced by a Metal Cation are also known as amides or azanides. The second sense of the word ''amide'' is the amide anion, which is a deprotonated form of ammonia or an amine. It is represented generally by the formula: {Link without Title} -, and is an extremely strong base, due to the extreme weakness of ammonia and its analogoues as Brønsted Acid s. The remainder of this article is about the carbonyl-nitrogen sense of ''amide''. For examples of the anionic amide, see the articles Sodium Amide and Lithium Diisopropylamide . AMIDE SYNTHESIS
AMIDE REACTIONS
AMIDE PROPERTIES An amide linkage is kinetically stable to Hydrolysis . However, it can be hydrolysed in boiling alkali, as well as in strong acidic conditions. Amide linkages in a Biochemical context are called Peptide Link ages. Amide linkages constitute a defining molecular feature of Protein s, the Secondary Structure of which is due in part to the hydrogen bonding abilities of amides. DERIVATIVES Sulfonamide s are analogs of amides in which the atom double bonded to oxygen is Sulfur rather than carbon. NAMING CONVENTIONS
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