| Acyl Carrier Protein |
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Information AboutAcyl Carrier Protein |
| CATEGORIES ABOUT ACYL CARRIER PROTEIN | |
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4'- Phosphopantetheine is an essential prosthetic group of several acyl carrier proteins involved in pathways of primary and secondary metabolism including the acyl carrier proteins (ACP) of fatty acid synthases, ACP of polyketide synthases, and peptidyl carrier proteins (PCP) and aryl carrier proteins (ArCP) of Nonribosomal Peptide Synthetases (NRPS). Phosphopantetheine fulfils two demands in these biosynthetic pathways. Firstly, the intermediates remain covalently linked to the synthases (or synthetases) in an energy-rich linkage. Secondly, the flexibility and length of phosphopantetheine chain (approximately 20 Å) allows the covalently tethered intermediates to have access to spatially distinct enzyme active sites. This increases the effective molarity of the intermediate and allows an assembly line like process. Structurally, the ACPs are small negatively charged α-helical bundle proteins with a high degree of structural and amino acid similarity. The solution phase structures of a number of acyl carrier proteins have been solved using various NMR and crystallography techniques. |
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