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Curtis was demonstrator of plants and Praefectus Horti at the Chelsea Physic Garden from 1771 to 1777. He Published '' The Botanical Magazine '' (founded in 1787 ) and ''Flora Londinensis'' (6 volumes, 1777 - 1798 ) - a pioneering work in that it devoted itself to urban nature. He established his own London Botanic Garden at Lambeth in 1779, moving to Brompton in 1789.

The genus '' Curtisia '' is named in his honour.