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Voriconazole
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Voriconazole (Vfend®, Pfizer ) is a Triazole Antifungal Medication used to treat serious Fungal Infection s. It is used to treat invasive fungal infections that are generally seen in patients who are Immunocompromised . These infections include invasive Candidiasis and Aspergillosis .


ADMINISTRATION

Oral (in tablets or suspension) or Intravenous . Voriconzole interacts with many medications, including drugs given to suppress the immune system in transplant patients (e.g. Cyclosporine , etc.).

Voriconazole is available as 50mg tablets and 200mg tablets. The oral suspension contains 200mg per 5ml. The intravenous preparation comes in vials containing 200mg of powder.


PHARMACOLOGY

Voriconazole is well absorbed ( Bioavailability 96%) and it has been said that measuring voriconazole levels is unnecessary. There is increasing evidence that this is untrue: children in particular seem to clear voriconazole faster than adults. It is suggested that clinicians should aim to achieve levels above 2.05µg/ml.