Titin


	Symbol	TTN
	HGNCid	12403
	Chromosome	2
	Arm	q
	Band	31
	OMIM	188840
	EntrezGene	7273
	RefSeq	NM_133378
	UniProt	Q8WZ42

Titin, also known as '''connectin''', ( that is important in the contraction of striated muscle tissues. Titin connects the Z line to the M line in the Sarcomere . The protein limits the range of motion of the sarcomere in Tension , thus contributing to the passive stiffness of muscle. Variations in the sequence of titin between different types of muscle (e.g. cardiac or skeletal) has been correlated with differences in the mechanical properties of the muscles {Link without Title} .

Titin is the largest known protein, consisting of 26,926 is C₁₃₂₉₈₃H₂₁₁₈₆₁N₃₆₁₄₉O₄₀₈₈₃S₆₉₃. It has a theoretical Instability Index (II) of 39.69, indicating that it would be stable in a Test Tube . The protein's In Vivo Half-life , the time it takes for half of the amount of protein in a cell to disappear after its synthesis in the cell, is predicted to be approximately 30 hours (in Mammalian Reticulocyte s). {Link without Title}

SOURCES

[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7569978 Labeit S, Kolmerer B, "Titins: giant proteins in charge of muscle ultrastructure and elasticity.", Science. 1995 270:293-6.

[http://us.expasy.org/cgi-bin/niceprot.pl?Q10466 Swiss-Prot Protein knowledgebase, main entry

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Titin