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Reactive Oxygen Species




ROSs form as a natural byproduct of the normal metabolism of Oxygen but can damage cell membranes by causing Oxidative Stress .
Cells are normally able to defend themselves against ROS damage through the use of the Enzymes Superoxide Dismutase (SOD) and Catalase .

The effects of ROS on cell metabolism have been well documented in a variety of species. These include not only roles in programmed cell death and Apoptosis , but also positive effects such as the induction of host defense Genes and mobilisation of ion transport systems. This is implicating them more frequently with roles in Oxidative Signalling . In particular, Platelets involved in Wound repair and Blood Homeostasis release ROS to recruit additional platelets to sites of Injury . These also provide a link to the adaptive Immune System via the recruitment of Leukocytes

Reactive oxygen species are implicated in cellular activity to a variety of inflammatory responses including Cardiovascular Disease and Hearing Impairment via Cochlea r damage induced by Elevated Sound Levels .


SEE ALSO



REFERENCES

  • Sen, C.K. (2003) The general case for redox control of wound repair, Wound Repair and Regeneration, 11, 431-438

  • Krötz, F., Sohn, HY., Gloe, T., Zahler, S., Riexinger, T., Schiele, T.M., Becker, B.F., Theisen, K., Klauss, V., Pohl, U. (2002) NAD(P)H oxidase-dependent platelet superoxide anion release increases platelet recruitment, Blood, 100, 917-924

  • Pignatelli, P. Pulcinelli, F.M., Lenti, L., Gazzaniga, P.P., Violi, F. (1998) Hydrogen Peroxide Is Involved in Collagen-Induced Platelet Activation, Blood, 91 (2), 484-490

  • Guzik, T.J., Korbut, R., Adamek-Guzik, T. (2003) Nitric oxide and superoxide in inflammation and immune regulation, Journal of Physiology and Pharmacology, 54 (4), 469-487