| Dose-response Curve |
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The measured dose (usually in Milligrams , Micrograms , or Grams per kilogram of body-weight) is generally plotted on the X axis and the response is plotted on the Y axis. Commonly, it is the Logarithm of the dose that is plotted on the X axis, and in such cases the curve is typically Sigmoidal , with the steepest portion in the middle. The first point along the graph where a response above zero is reached is usually referred to as a Threshold-dose . For most beneficial or recreational drugs, the desired effects are found at doses slightly greater than the threshold dose. At higher doses still, undesired side effects appear and grow stonger as the dose increases. The stronger a particular substance is, the steeper this curve will be. In quantitative situations, the Y-axis usually is designated by percentages, which refer to the percentage of users registering a standard response (which is often death, when the 50% mark refers to LD50 ). Interactive dose-response curve |