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The widespread introduction of antiseptic Surgical methods followed the publishing of the paper '' Antiseptic Principle Of The Practice Of Surgery '' in 1867 by Joseph Lister , inspired by Louis Pasteur 's germ theory of putrefaction. Some of this work was preceded slightly by that of Dr. George H Tichenor and Ignaz Semmelweis .

For the growth of bacteria there must be a certain food supply, moisture, in most cases oxygen, and a certain minimum temperature (see Bacteriology ). These conditions have been specially studied and applied in connection with the Preserving Of Food and in the ancient practice of Embalming the dead, which is the earliest illustration of the systematic use of antiseptics.

In early inquiries a great point was made of the prevention of putrefaction, and work was done in the way of finding how much of an agent must be added to a given solution, in order that the bacteria accidentally present might not develop. But for various reasons this was an inexact method, and to-day an antiseptic is judged by its effects on pure cultures of definite pathogenic microbes, and on their vegetative and spore forms. Their standardization has been effected in many instances, and a water solution of Phenol of a certain fixed strength is now taken as the standard with which other antiseptics are compared.

Some common antiseptics are:

  • Alcohol : Used to disinfect the skin before injections are given, often along with iodine.

  • Quaternary Ammonium Compounds (such as Benzalkonium Chloride ): Used as a pre-operative skin disinfectant. Antiseptic towels are often impregnated with this chemical.

  • infections of the Vagina , in eyewashes, and as an antiviral to shorten the duration of Cold Sore attacks. Put into creams for burns. Also common in trace amounts in eye contact solution. Though it is popularly known as an antiseptic, it is in reality only a soothing fluid, and bacteria will flourish comfortably in contact with it.

  • )

  • s. More common 1% or 2% solutions of hydrogen peroxide have been used in household first aid for scrapes, etc. However, even this less potent form is no longer recommended for typical wound care as the strong oxidization causes scar formation and increases healing time. Gentle washing with mild soap and water or rinsing a scrape with sterile saline is a better practice.

  • solution or as Lugol's Iodine solution as a pre- and post-operative antiseptic. No longer recommended to disinfect minor wounds because it induces scar tissue formation and increases healing time. Gentle washing with mild soap and water or rinsing a scrape with sterile saline is a better practice.

  • due to concerns about its Mercury content.


  • Sodium Chloride : Used as a general cleanser. Also used as an antiseptic mouthwash.

  • Sodium Hypochlorite


But every antiseptic, however good, is more or less toxic and irritating to a wounded surface. Hence it is that the "antiseptic" method has been replaced in the Surgery of to-day by the "aseptic" method, which relies on keeping free from the invasion of bacteria rather than destroying them when present.


References