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Walther Flemming




Walther Flemming (born April 21 1843 in Sachsenberg , Germany ; died August 4 1905 in Kiel ) was a founder of the study of Cytogenetics .

He was born as the fifth child and only son of the Psychiatrist Carl Friedrich Flemming (1799-1880) and his second wife, Auguste Winter. He did his basic studies at the ''Gymnasium der Residenzstadt'', where one of his colleagues and lifelong friends was writer Heinrich Seidel {Link without Title} .

Flemming trained in Medicine at the University Of Rostock , graduating in 1868 . Afterwards. he served in 1870-1871 as a military physician at the Franco-Prussian War . From 1873 to 1876 he worked as a teacher at the University Of Prague . In 1876 he accepted a post as a professor of Anatomy at the University Of Kiel , where he stayed until 1901 , shortly before his death, and where he became the director of the Anatomical Institute.

Making use of Aniline Dye s he was able to find a structure which strongly absorbed Basophilic dyes, which he named Chromatin . He identified that chromatin was correlated to threadlike structures in the Cell Nucleus — the Chromosomes (meaning ''coloured body''), which were thus named later on by German anatomist Wilhelm Von Waldeyer-Hartz (1836-1921). The Belgian scientist Edouard Van Beneden (1846-1910) had independently observed them, too.

Flemming investigated the process of Cell Division and the splitting of chromosomes into identical halves. He called this process Mitosis from the Greek word for thread. He studied mitosis both '' In Vivo '' and in stained preparations, using as the source of biological material the Fin s and Gill s of Salamander s. These results were published in 1882 in the seminal book ''Zell-substanz, Kern und Zelltheilung'' (1882; Cytoplasm, Nucleus and Cell Division). On the basis of his discoveries, Flemming surmised for the first time that all cell nuclei came from another predecessor nucleus (he coined the famous catch phrase ''omnis nucleus e nucleo'').

Flemming was unaware of 's (1834-1914) discovery of Meiosis , Theodor Schwann (1810-1882) and Matthias Schleiden 's (1804-1881) Cell Theory and Thomas Hunt Morgan 's (1866-1945) first Genetic Map s).

Flemming's name is honoured by a medal awarded by the German Society For Cell Biology (Deutschen Gesellschaft für Zellbiologie).


REFERENCES

  • Paweletz, N. Walther Flemming, Pioneer of Mitosis Research. ''Nature Reviews Molecular Cell Biology'' 2, 72-75 (2001) PMID 11413469. ( Full text article for subscribers of Nature )

  • Flemming, W. Beitrage zur Kenntniss der Zelle und ihrer Lebenserscheinungen. ''Arch. Mikroskop. Anat.'' 16:302-436 (1878) and 18:151-289 (1880). Reprinted in: ''J. Cell Biol.'' 25:581-589 (1965).

  • Carlson, E.A. The Analysis of Mitosis Shifts Attention to the Chromosomes. In: ''Mendel's Legacy. The Origins of Classical Genetics''. p. 24-5, CSHL Press, 2004. ISBN 0879696753.



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