Information AboutSyntex |
| CATEGORIES ABOUT SYNTEX | |
| syntex | |
| pharmaceutical companiessyntex | |
| pharmaceutical companies | |
| pharmaceutical companies of mexico | |
| SHOPPER'S DELIGHT | |
|
RUSSELL MARKER Russell Marker left the company and took his notebooks in a disagreement over compensation. GEORGE ROSENKRANZ George Rosenkranz had studied at the Swiss Federal Institute of Technology and was conducting pharmaceutical research in Cuba. He joined Syntex to replace marker and hired Djerassi. CARL DJERASSI Carl Djerassi went to work at Syntex in 1949 as their associate director of chemical research. He performed the first synthesis of an Oral Contraceptive on October 15 , 1951 . The steroid was 19-nor-17 alpha-ethynyltestosterone, with the generic name of norethistrone and norethindrone. BIRTH CONTROL PILL Syntex submitted their compound to a laboratory in Madison, Wisconsin , for biological evaluation, and found it was the most active, orally-effective progestational hormone of its time. Syntex submitted a patent application in November of 1951. G.D. Searle & Co. filed for a patent for the synthesis of the double bond isomer 13 of norethindrone called norethynodrel in August of 1953. Norethynodrel is converted into norethindrone under acidic conditions, and their new patent didn't infringe on Syntex's. Searle obtained approval to market norethynodrel before Syntex received their approval. By 1964, 3 companies including Syntex were marketing 2 mg doses of Syntex's norethindrone. Syntex chemists synthesized cortisone from Diosgenin , a phyosteroid contined in Mexican yams. This synthesis was a more economical than the previous Merck & Co. synthesis. REFERENCES
|