- Simon Of Trent
- Simón Bolívar , liberator of South America
- Simon Burnett , British swimmer
- Simon Dubnow , Jewish historian
- Simon Hughes , British politician
- Simon Le Bon , the lead singer of Duran Duran
- Simon Magus , Samaritan (Proto-)Gnostic
- Leonard Simon Nimoy , American Actor , Film Director , Poet and Photographer best known for playing the character Spock in the '' Star Trek '' Franchise
- Simon Wiesenthal , Nazi hunter
- Simon Wilcox , Canadian musician
- Carly Simon , American musician
- Claude Simon , French writer
- Herbert Simon , cognitive psychologist and polymath
- John Allsebrook Simon, 1st Viscount Simon , Lord Chancellor of Great Britain 1940–45, and several of his descendants who also held the title of Viscount Simon
- John Simon , author and literary, film and drama critic
- John Simon , record producer for Columbia Records
- Sir John Simon , Chief Medical Officer for England, 1855 - 1876
- Jules Simon , French statesman and philosopher
- Neil Simon , American playwright and screenwriter
- Norton Simon , American industrialist
- Richard Simon , French biblical critic
- Paul Simon of Simon And Garfunkel , musician
- Paul Simon , US senator
- Simon , electronic game launched in 1978 at Studio 54 in New York
- Simon Says , popular children's game
- Simon , Chess Engine
- La Maison Simons , Canadian Fashion retailer
- Simon Grenade , wall breaching Rifle Grenade
- Simon Property Group , retail management company which owns numerous malls and Shopping Centers across the United States
- Simple Simon , well-known Nursery Rhyme
- '' Simple Simon '', Broadway Musical
- Simple Simon , variant of card solitaire
- ''Simple Simon'', song by 1910 Fruit Gum Company
- Simon, slang term used to refer to a man who wears women's clothing for comfort reasons
- Simon, Metropolitan Of Moscow
- Simon , a radio station in Greensboro, North Carolina that operates at 98.7 MHz .
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