- S-Allyl Cysteine , a chemical constituent of garlic
- SAC Capital Partners , a hedge fund managed by Steven A. Cohen
- SAC Programming Language
- St. Andrew's College
- School Advisory Council
- School Assesed Coursework in the Victorian Certificate Of Education
- Secure Authenticated Channel
- Senior Aircraftman
- Senior Assistant Commissioner , a rank in the Singapore Police Force
- Simple API For CSS , a way for programmers to work with Cascading Style Sheets
- Societas Apostolatus Catholici, a religious congregation also known as the Pallottines
- Special Area Of Conservation , as laid down by the EU Habitats Directive of May 1992
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- Statement Of Accounting Concepts
- Strategic Air Command
- Strict Avalanche Criterion, a strict definition of the Avalanche Effect in cryptography
- Student Activity Center , often found on college campuses
- Student Advisory Council, at Northern Illinois University
- Students' Administrative Council, University Of Toronto
- Sukhoi Aviation Corporation
- Superior Art Creations , an underground group of computer art scene enthusiasts
- Sveriges Arbetares Centralorganisation , the Central Organization of Swedish Workers
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