- Metis (mythology) , a Titaness and the first wife of Zeus
- Metis (moon) , the innermost of Jupiter's known moons
- 9 Metis , an asteroid
- Métis , sometimes used to refer to '' Mestizo '' — people of mixed race
- Métis People , a Canadian ethnic group.
- Metis Shoal , the tip of a submarine volcano in Tonga, which occasionally erupts to form the temporary island Late'iki (Metis Island).
- '', published by White Wolf . Among most shifters they are deformed and sterile. Among werewolves, they are scorned and treated like second class citizens.
- Metis (modelling) , an enterprise modelling tool
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