Information About

Methemoglobinemia




  ICD10
  ICD9
  ICDO
  Image
  Caption
  OMIM
  MedlinePlus 000562
  EMedicineSubj emerg
  EMedicineTopic 313
  DiseasesDB 8100


Methemoglobinemia, also known as "met-H", is a usually Gene tic Blood disorder characterized by the presence of a higher than normal level of Methemoglobin in the blood.


TYPES


Congenital methaemoglobinaemia ()

Due to an Enzyme deficiency, the blood of met-H victims has reduced Oxygen -carrying capacity. Instead of being red in colour, the arterial blood of met-H victims is brown. This results in the Skin of Caucasian sufferers gaining a bluish cast. Hereditary met-H is caused by a Recessive Gene . If only one parent has this gene offspring will have normal-hued skin, but if both parents carry the gene there is a chance the offspring will have blue-hued skin.

Types include:


Acquired/Toxic methaemoglobinaemia ()

Acquired methemoglobinemia can be caused by the use of Nitrite -containing drugs, such as Amyl Nitrite . Nitrates do not cause methemoglobinemia.

It can be caused by drinking water nitrate-nitrogen levels that exceed current EPA standards of 10ppm. Nitrate can cause the reaction in the bloodstream, especially in babies.


TREATMENT

Methemoglobinemia is treated with the use of Methylene Blue , which restores the hemoglobin to its normal oxygen-carrying state.


SYMPTOMS


<1.7% : Normal

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10-20% : Blueish skin

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20-40% : headache, weakness, dizzyness

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>35% : breathlessness, weakness

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50-60% : Coma, Sezurees, shivering, unusual heart rates

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>70% : Death