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Maria Manuela of Portugal ( Princess daughter of King John III Of Portugal and his wife Catherine Of Habsburg . She is also known as Maria Manuela.

Maria was born in Coimbra on October 15 1527 and was one of the few children of John III to survive childhood. She married Philip II Of Spain (future Philip I of Portugal) and was the mother of Prince Carlos , a deformed child that was heir of the Spanish crown.

Maria died soon after she gave birth on August 12 1545 in Valladolid , Spain .