- If-Modified-Since {Link without Title} , a HTTP/1.1 header field used (by Caches ) to suppress download of unaltered objects
- Immunomagnetic Separation , a laboratory test
- IMTEK Mathematica Supplement , Open Source Mathematica packages and tutorials
- Independent Media Support or IMS media, a UK provider of access services to the media
- The Indianapolis Motor Speedway
- Industrial Methylated Spirit
- Information Management System , a combination Database Management System and Transaction Processing system from IBM
- Inventory Management System , a combination Database Management System in relation to Telco OSS/BSS
- Institute Of Mathematical Statistics
- Instructional Management Systems , broadly distributed distance learning standards (see IMS Global )
- Insulated Metal Substrate , a substrate used in Power Electronics applications.
- Intelligent Mechatronic Systems , a University Of Waterloo spin-off company based in Waterloo, Ontario
- International Measurement System , a handicapping system for Yacht Racing .
- Internet Medieval Sourcebook , a web archive of Medieval source documents
- Intramuscular Stimulation , an enhanced Acupuncture technique used in Physiotherapy for pain treatment
- Ion Mobility Spectrometer , a highly sensitive analytical instrument
- IP Multimedia Subsystem , a set of specifications from 3GPP
- Irish Mathematical Society of Ireland
- Irish Marching Society of Rockford, Illinois
- Irritable Male Syndrome , the male equivalent of PMS
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