- Dieter Heß , German botanist
- Erika Hess , Swiss alpine skier
- Germain Henri Heß (1802-1850), Russian-Swiss chemist
- Harry Hess , a geologist best known for his theories on Sea Floor Spreading .
- Heinrich Von Heß , Austrian fieldmarshall
- Heinrich Maria Von Hess , German painter
- Jared Hess , writer and director of Napoleon Dynamite
- Johann Hess (Hesse), (1490-1547)
- Johann Jakob Hess , (1741-1828)
- Markus Hess , German hacker
- Moses Heß ( Moses Hess ), Jewish philosopher and proto- Zionist
- Myra Hess , British pianist
- Peter Von Hess , German Painter
- Richard Heß , German sculptor
- Rudolf Hess , a high-ranking Nazi during World War II
- Victor Hess ( Victor Franz Hess ), an Austrian-American physicist who discovered Cosmic Rays .
- Walter Rudolf Hess , Nobel Prize winner in medicine
- Wolf Rüdiger Heß , German architect, right extremist and son of Rudolf Hess
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