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Deletion of a number of base pairs that is not evenly divisible by three will lead to a Frameshift mutation, causing all of the Codon s occurring after the deletion to be read incorrectly during Translation , producing a severely altered and potentially nonfunctional Protein .

Deletions are responsible for an array of genetic disorders, including some cases of male Infertility and two thirds of cases of Duchenne Muscular Dystrophy (Lewis, 2005, p.226). A deletion of part of the short arm of chromosome 5 results in Cri Du Chat (Lewis, 2005, p.256).


REFERENCE

  • Lewis R. 2005. ''Human Genetics: Concepts and Applications'', 6th Ed. McGraw Hill, New York.