Chromosomal Inversion

Paracentric inversions do not include the Centromere and both breaks occur in one arm of the chromosome. Pericentric inversions include the centromere and there is a break point in each arm. Special Cytogenetics techniques are often needed to detect inversions.

Inversions usually do not cause any abnormalities in carriers as long as the rearrangment is balanced with no extra or missing genetic information. However, there is an increased chance for the production of unbalanced chromosome rearrangements in the offspring of carriers. Families that may be carriers of inversions may be offered Genetic Counseling and Genetic Testing .

The most common inversion seen in humans is on chromosome 9, at inv(9)(p11q12). This inversion is generally considered to have no deleterious or harmful effects, but there is some evidence it leads to an increased risk for miscarriage for about 30% of affected couples.

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Chromosomal Inversion