| Creb |
Articles about Creb |
Information AboutCreb |
| CATEGORIES ABOUT CREB | |
| transcription factors | |
| SHOPPER'S DELIGHT | |
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CREB ( such as cAMP or Ca2+ , which in turn activates a Protein Kinase . This protein kinase moves to the Cell Nucleus , where it activates a CREB protein. The activated CREB molecule then binds to a CRE element, and is then bound to by a CBP (CREB binding protein) which coactivates it, allowing it to switch certain genes on or off. The DNA binding of CREB is mediated via its basic Leucine zipper domain ( BZIP Domain ) as depicted on the picture. CREB proteins in Neuron s are involved in the formation of long-term memories; this has been shown in the marine snail '' Aplysia '', the fruit fly '' Drosophila Melanogaster '', and in Rats . They are necessary for the late stage of Long Term Potentiation . There are activator and repressor forms of CREB. Fruit flies genetically engineered to overexpress the activator form have been shown to learn significantly faster than wild-type flies: they readily form long-term memories after only a single training, while wild-type flies require several spaced repetitions. In humans, abnormalities of the CREB protein gene CBP is associated with Rubenstein-Taybi Syndrome . REFERENCES ( "Opening Skinner's Box" by Laren Slater |