1540s

|-
| align="center" | - 16th Century ''' - 17th Century

|-
| align="center" colspan=2 | Decades :

1510s 1520s 1530s - 1540s - 1550s 1560s 1570s
|-
| align="center" colspan=2 | Years:

1540 1541 1542 1543 1544 1545 1546 1547 1548 1549
|}

Events and Trends

1541 Hernando De Soto is the first European to see the Mississippi River .

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