|-
| align="center" colspan=2 | Years:
1516 1517 1518 - 1519 - 1520 1521 1522
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| align="center" colspan=2 | 1490s 1500s - 1510s ''' - 1520s 1530s 1540s
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| align="center" | - 16th Century ''' - 17th Century
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Events
Births
- February 5 - René Of Châlon , Prince of the House of Orange (d. 1544 )
- February 16 - Gaspard De Coligny , French Huguenot leader (died 1572 )
- February 17 - Francis, Duke Of Guise , French soldier and politician (d. 1563 )
- March 31 - King Henry II Of France (died 1559 )
- April 13 - Catherine De Medici , queen of Henry II Of France (died 1589 )
- May 27 - Girolamo Mei , Italian humanist historian (died 1594 )
- June 6 - Andrea Cesalpino , Italian philosopher, physician, and botanist (died 1603 )
- June 12 - Cosimo I De' Medici, Grand Duke Of Tuscany (died 1574 )
- June 24 - Theodore Beza , French theologian (died 1605 )
- July 22 - Pope Innocent IX (died 1591 )
- Thoinot Arbeau , French priest and author (died 1596 )
- Thomas Gresham , English merchant and financier (died 1579 )
- Nicholas Grimald , English poet (died 1562 )
- Pedro Menéndez De Avilés , first Spanish Governor of Florida
- Ikeda Nagamasa , Japanese military commander (died 1563 )
- Edwin Sandys , English prelate (died 1588 )
- Imagawa Yoshimoto , Japanese warlord
- Stanislaw Zamoyski , Polish nobleman (died 1572 )
Deaths
- January 12 - Maximilian I, Holy Roman Emperor (born 1459 )
- January 21 - Vasco Núñez De Balboa , Spanish explorer
- May 2 - Leonardo Da Vinci , Italian inventor and painter (born 1452 )
- May 4 - Lorenzo II De' Medici , Duke of Urbino (b. 1492 )
- June 24 - Lucrezia Borgia , Duchess of Ferrara (born 1480 )
- August 11 - Johann Tetzel , German opponent of the Reformation (born 1465 )
- August 23 - Philibert Berthelier , Swiss patriot
- September 10 - John Colet , English churchman and educator
- Francesco II Of Gonzaga , Marquis of Mantua (born 1466 )
- William Grocyn , English scholar (born 1446 )
- Ambrosius Holbein , German painter (born 1494 )
- Lorenzo II De' Medici , Duke of Urbino (born 1492 )
- Alonso Alvarez De Pineda , Spanish explorer and cartographer (born 1494 )
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