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The film has two basic storylines. One follows the efforts of a group of civilians to stay alive during the disaster; the other follows the efforts of political and military leaders to contain the Epidemic of violent insanity induced by the weapon.

As often in Romero's work (e.g. '' Day Of The Dead ''), the military are subjected to withering Satire . Ordered to find the first expert they can lay hands on and convey him to the stricken town, the soldiers do precisely that, thus isolating the one man who might be able to find a cure in the middle of a disaster area with primitive facilities. The scientist's protests that he will be more useful in a proper laboratory are overridden with the threat of brute force.

The military response to the outbreak is to cordon off the town and shoot anyone who tries to escape, which has the effect of escalating the panic. One man, who seems to be immune to the nerve gas, is among those trying to flee, but by the time he is brought to the military clinic chaos has taken over and the problem seems to be spreading.