In humans, the gene that encodes for TRAIL is located at Chromosome 3q26.
TRAIL binds to the Death Receptor s, DR4 and DR5. The process of apoptosis is Caspase-8 -dependent.
REFERENCES
PMID 8777713 - Wiley SR et al. ''Identification and characterization of a new member of the TNF family that induces apoptosis.'' Immunity. 1995 Dec;3(6):673-82.