- Pro Tools TDM , an audio effects plug-in architecture based on Time Division Multiplexing and created by Digidesign for their popular Pro Tools Digital Audio Workstation
- Time-division Multiplexing , a method for sending multiple digital signals along a single telecommunications transmission path
- Therapeutic Drug Monitoring , a branch of clinical chemistry
- Tucker Death Mix , a cocktail drink
- In the game Far Cry , "Team Death Match", a multiplayer mode where points are scored by killing members of an opposing team
- Transportation Demand Management , changing or reducing demand for car use by encouraging the behavioural change of household choices of travel.
- Yamaha TDM , a motorcycle
- Teledifusão De Macau ( Portuguese for "Television of Macau"), one of the major television stations in Macau , China
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