- Argentina
- --- Santiago Del Estero
- --- Santiago Del Estero Province
- Brazil
- --- Santiago, Rio Grande Do Sul
- Cape Verde :
- --- Santiago, Cape Verde , a parish of the municipality of Santa Cruz in Santiago Island (Cape Verde)
- Chile
- --- Santiago (municipality)
- --- Santiago Province, Chile
- --- Region Metropolitana De Santiago , an administrative region of Chile
- Cuba
- --- Santiago De Cuba
- Dominican Republic
- --- Santiago De Los Caballeros
- --- Santiago Province, Dominican Republic
- Ecuador
- --- Santiago Island (Galápagos)
- Guatemala
- --- Santiago Sacatepéquez
- Mexico
- --- Santiago De Querétaro (formerly, "Querétaro")
- --- Santiago, Nuevo León
- --- Santiago, Baja California Sur
- Panama
- --- Santiago De Veraguas
- Peru
- --- Santiago De Surco is a district of Lima
- --- Santiago De Chuco , a district of La Libertad , where poet César Vallejo was born.
- Philippines
- --- Santiago, Agusan Del Norte
- --- Santiago, Ilocos Sur
- --- Santiago City , Isabela
- --- Santiago Island (Philippines)
- Portugal
- --- Santiago (Alcácer Do Sal) , a parish in the municipality of Alcácer Do Sal
- --- Santiago (Arganil) , a parish in the municipality of Arganil
- --- Santiago (Armamar) , a parish in the municipality of Armamar
- --- Santiago (Lisbon) , a parish in the municipality of Lisbon
- --- Santiago (Seia) , a parish in the municipality of Seia
- --- Santiago (Sesimbra) , a parish in the municipality of Sesimbra
- --- Santiago (Tavira) , a parish in the municipality of Tavira
- --- Santiago (Torres Novas) , a parish in the municipality of Torres Novas
- --- Santiago Da Guarda , a parish in the municipality of Ansião
- --- Santiago Da Ribeira De Alhariz , a parish in the municipality of Valpaços
- --- Santiago De Besteiros , a parish in the municipality of Tondela
- --- Santiago De Bougado , a parish in the municipality of Trofa
- --- Santiago De Candoso , a parish in the municipality of Guimarães
- --- Santiago Do Cacém , a parish and a municipality in the Setúbal (district)
- --- Santiago De Carreiras , a parish in the municipality of Vila Verde
- --- Santiago De Cassurrães , a parish in the municipality of Mangualde
- --- Santiago De Figueiró , a parish in the municipality of Amarante
- --- Santiago De Litém , a parish in the municipality of Pombal
- --- Santiago De Montalegre , a parish in the municipality of Sardoal
- --- Santiago De Piães , a parish in the municipality of Cinfães
- --- Santiago De Riba-Ul , a parish in the municipality of Oliveira De Azeméis
- --- Santiago De Subarrifana , a parish in the municipality of Penafiel
- --- Santiago De Vila Chã , a parish in the municipality of Ponte Da Barca
- --- Santiago Do Escoural , a parish in the municipality of Montemor-o-Novo
- --- Santiago Dos Velhos , a parish in the municipality of Arruda Dos Vinhos
- --- São Pedro E Santiago , a parish in the municipality of Torres Vedras
-- Santiago Maior
- --- Santiago Maior (Alandroal) , a parish in the municipality of Alandroal
- --- Santiago Maior (Beja) , a parish in the municipality of Beja
- --- Santiago Maior (Castelo De Vide) , a parish in the municipality of Castelo De Vide
- --- Vale De Santiago , a parish in the municipality of Amarante
- Spain
- --- Asturia :
-- Santiago (Valdés) , a parish in the municipality of Valdés
-- Santiago (Sariego) , a parish in the municipality of Sariego
- ---Other
-- Santiago De La Ribera , a cluster of San Javier in Murcia
-- Santiago (comarca) , a Comarca in the province of A Coruña , Spain
- --- Canary Islands
-- Santiago Del Teide , a municipality in the island of Teide in the province of Santa Cruz De Tenerife
- Santiago was the Spanish name given to the island of Xamayca, now called Jamaica
- Santiago was the Spanish Battle Cry
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