- Secure Sockets Layer , a communications protocol.
- Space Sciences Laboratory in Berkeley, California .
- S/SL , a programming language.
- Solid State Logic , a manufacturer of mixing consoles.
- Swedish Sign Language , a sign language used in Sweden.
- Selangor Sign Language , a sign language used in Malaysia.
- SSL International , a consumer healthcare manufacturer, owning brands like Durex and Scholl
- Single Stuck Line , a fault model for Digital Circuits .
- Solid State Lighting , a lighting technology that utilizes a cluster of LEDs.
- System Simulation Ltd , a software engineering company
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