- Short Message Service , a form of text messaging on cell phones
- Sega Master System – an 8-bit video game console from the 1980s
- ''Seiner Majestät Schiff'' , "His Majesty's Ship" in the German Kaiserliche Marine and the Austro-Hungarian Navy
- SMS (comics) , a British comic book illustrator
- Sixth Man Syndrome , in ''Star Trek'', the unfortunate fate of many a crew member who accompanied the five-man crew
- Southwest Missouri State University , the state's second largest university
- Stranka Mladih Slovenije , Youth Party of Slovenia political party
- System Management Services , firmware code for the IBM RS/6000 machines
- Systems Management Server , Microsoft product to manage remotely Microsoft-based computer systems
- ''Sonar Middleware Standard'', a publication of the Naval Undersea Warfare Center
- Standard Modular System , a system of standard transistorised circuit boards developed by IBM in the late 1950s
- Sudden Motion Sensor , a patented feature of Apple Computer’s notebooks, which prevents hard-disk failures when the notebook is dropped
- Super Mario Strikers , a 2005 Mario spinoff soccer/football game for the GameCube
- Super Mario Sunshine , a 2002 Mario game for the GameCube
- Smith-Magenis Syndrome , a genetic disorder
- Sting Millennium Suite , a bioinformatics software
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