- Bob Smith (doctor) (1879–1950), founder of Alcoholics Anonymous
- Robert Smith (mathematician) (1689–1768), English mathematician
- Robert Smith, Bishop (1732–1801), Episcopal Bishop
- Robert Smith (architect) , American architect who designed Nassau Hall in Princeton, New Jersey and Carpenter's Hall in Philadelphia, Pennsylvania
- Robert Paul Smith (1915–1977), American writer
- Robert Thomas Smith (born 1949), Church leader/theologian
- Robert E. Smith (c. 1918–c. 2004), American pilot in the RAF and USAF
- Robert E. Smith (1910–?), typographer who designed the fonts Brush Script and Park Avenue .
- Robert J. Smith (anthropologist)
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