- Rensselaer Polytechnic Institute , the Troy, New York university.
- Rose Polytechnic Institute , the Terre Haute, Indiana college.
- Retail Price Index , also known as the consumer price index, a statistical measurement.
- Roleplay Intensive MUDs
- Roll Position Indicator , a machinery term.
- Repetitive motion injury, usually RSI
- Revista Da Propriedade Industrial
- Rockwell Protocol Interface , a Modem feature.
- Ratings Percentage Index , the NCAA ranking system.
- Revenue Protection Inspector , the United Kingdom Public Transit patrol.
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