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- Kirk Acevedo , actor, (T.V. series '' Oz '')
- Jose Miguel Agrelot , "''Don Cholito''", comedian
- Miguel Angel Alvarez "El Men", comedian
- Victor Argo , actor ('' King Of New York '')
- Raymond Arrieta , comedian
- Rick Aviles , actor/comedian ('' Ghost '')
- Charlotte Ayanna , actress
- Adrienne Bailon , member of Platnium R&B group 3LW ,Actress
- Alba Raquel Barros , comedian/actress
- Ivonne Belen , documentary director and producer
- Lucy Boscana , actress, pioneer in Puerto Rico's television
- Giselle Blondet , actress/TV host
- Norma Candal , comedian
- Irene Cara , singer/actress ('' Fame '')
- Desiree Casado , actress ''"Gaby"'' on Sesame Street , film '' I Like It Like That ''
- Myrna De Casenave , actress/comedian, pioneer of Puerto Rican television
- Jorge Castro , soap opera actor
- Braulio Castillo , soap opera actor
- Braulio Castillo, Hijo , soap opera actor
- Melwin Cedeño , comedian
- Ivonne Coll , actress ('' The Godfather II '')
- Miriam Colon , actress ('' Scarface '')
- Paquito Cordero , TV producer/comedian
- Mapita Cortes , actress, niece of Mapy Cortes
- Mapy Cortes , actress
- Mara Croatto , soap opera actress
- Alexis Cruz , actor " Stargate " (TV series " Stargate SG1 ", " Touched By An Angel ")
- Wilson Cruz actor (TV series '' My So-Called Life ''; film Party Monster )
- Blanca De Castejon , international actress
- Henry Darrow , actor, "''Manolito''" (TV series '' The High Chaparral '')
- Raul Davila . actor, (TV series '' All My Children )''
- Rosario Dawson , actress ('' Men In Black '','' The Rundown '') Puerto Rican grandparent
- Michael DeLorenzo , actor (TV series '' New York Undercover ,'' '' Head Of The Class )''
- Sully Diaz , soap opera actress
- Lydia Echevarria , soap opera actress
- Hector Elizondo , actor ('' Pretty Woman '', '' The Princess Diaries '')
- Erik Estrada , actor (TV series '' CHiPs '', '' Sealab 2021 '')
- José Ferrer , actor ('' Cyrano De Bergerac ''), first Hispanic actor to win an Academy Award
- Miguel Ferrer , ('' RoboCop '', '' The Manchurian Candidate '')
- Franky G , actor ( The Italian Job (2003 Film) , Saw II )
- Rick Gonzalez , actor ('' The Rookie '', '' Coach Carter '')
- Bruce Gray , actor, S.W.A.T (born and raised in Puerto Rico)
- Luis Guzman , actor ('' Carlito's Way '', '' Traffic '', '' The Count Of Monte Cristo '')
- Juano Hernandez , actor, the first Puerto Rican star in the Negro Film Industry
- Lillian Hurst , comedian/actress ('' Dharma And Greg '')
- Raúl Juliá , actor ('' Kiss Of The Spider Woman '', '' The Addams Family '')
- Eva LaRue , actress of Puerto Rican descent ('' All My Children '')
- John Leguizamo , actor ('' Moulin Rouge! '', '' To Wong Foo, Thanks For Everything! Julie Newmar '') (Puerto Rican on Father's side)
- Adamari Lopez , actress of soap operas
- Jennifer López , actress ('' Selena '', '' The Cell '')
- Sunshine Logroño , comedian
- Justina Machado , actress (T.V. series '' Six Feet Under '') Final Destination 2 , Torque
- Sonia Manzano , actress, ''"Maria"'' on Sesame Street
- Eddie Marrero , actor (''Navy Seals: Untold Stories'')
- Javier Grillo-Marxuach , television and film producer
- Claribel Medina , actress soap operas
- John Melendez , "Stuttering John" (" Howard Stern Show " and " The Tonight Show ")
- Angela Meyer , actress, comedian and producer
- Ari Meyers , actress (TV series '' Kate & Allie '')
- Eddie Miro , T.V. Host
- Esai Morales , actor ('' La Bamba '')
- Jacobo Morales , actor ('' Bananas '')
- Alicia Moreda , soap opera actress
- Rita Moreno , actress, winner of an Oscar , a Tony Award , an Emmy Award and a Grammy Award
- Coati Mundi , composer/musician and actor (film Who's That Girl )
- Frankie Muniz , actor (TV series '' Malcolm In The Middle '') films Agent Cody Banks , Big Fat Liar (Puerto Rican on father's side)
- Rafo Muñiz , comedian
- Tommy Muñiz , T.V. producer/comedian
- Michael J. Narvaez , actor/director, film '' I Believe In America ''
- Micaela Nevárez , actress, film '' Princesas '', first Puerto Rican to win a Goya Award
- Jimmy Nieves , comedian, Radio and TV host
- Marian Pabon , actress
- Rosie Perez , actress ('' White Men Can't Jump '', '' Fearless '')
- Joaquin Phoenix , actor ('' Signs '', '' Gladiator '') (born in Puerto Rico)
- Freddie Prinze , comedian/actor (TV series '' Chico And The Man '') (Puerto Rican mother)
- Freddie Prinze, Jr. , actor ('' Scooby-Doo '') (Puerto Rican grandmother)
- Carmen Belen Richardson , comedian/actress
- Chita Rivera , " Broadway Legend", winner of 2 Tony Award s
- Luis Antonio Rivera , "Yoyo Boing" comedian
- Ramón (Diplo) Rivero , comedian
- Adalberto Rodríguez , "''Machuchal''" comedian
- " Roswell " " Resurrection Blvd. ")
- Freddie Rodríquez , actor (T.V. series '' Six Feet Under '')
- Gladys Rodríguez , comedian/soap opera actress
- Michelle Rodríquez , actress ('' The Fast And The Furious '')
- Esther Sandoval , actress
- Antonio Sanchez , comedian/television host
- Marcelino Sanchez , actor (" The Warriors "," Bloodhound Gang "
- Roselyn Sanchez , actress ('' Rush Hour 2 '')
- Jose Vega Santana , "" the Clown, (also see: '''Cartoonists''')
- Jon Seda , actor ('' Selena '')
- Henry Silva , actor ('' The Manchurian Candidate '', '' Dick Tracy (film) '')
- '')
- Talisa Soto , actress/model, ('' Licence To Kill '','' Mortal Kombat '')
- Miguel Ángel Suárez , actor ('' Stir Crazy '', '' Under Suspicion '')
- Rachel Ticotin , actress ('' Total Recall '', '' Con Air '')
- Benicio Del Toro , actor ('' Traffic ''), Academy award winner
- Liz Torres , actress (T.V. series '' Gilmore Girls '')
- Alanna Ubach , actress ('' Meet The Fockers '' (mother is Puerto Rican)
- Lauren And Loraine Velez , actress's, (T.V. series "New York Undercover", " Oz ")
- Christina Vidal ,actress, (TV series '' Taina '')
- Lisa Vidal , actress (''Night in the City''), (TV series '' ER '')
- Luis Vigoreaux , TV host
- Luisito Vigoreaux , TV host
- Sylvia Del Villard , actress, dancer and choregrapher
- Otilio Warrington , "''Bizcocho''" comedian
- Sandra Zaiter , TV host of children shows
- Abelardo Diaz Alfaro , writer
- Miguel Algarín , poet,writer and co-founder of the Nuyorican Poets Cafe
- Dr. Manuel A. Alonso , poet and author
- Maria Bibiana Benitez , playwright and Puerto Rico's "first" poetess
- Jose Gautier Benitez , poet
- Tomas Blanco , writer and historian
- Dr. Salvador Brau , historian
- Julia De Burgos , poet
- Mayra Calvani , writer
- Nemesio Canales , essayist and poet
- Judith Ortiz Cofer , poet, writer and essayist
- Dr. Cayetano Coll Y Toste , historian and writer
- Jesús Colón , writer, father of " Nuyorican " movement
- Juan Antonio Corretjer , poet
- Dr. José Antonio Dávila , poet
- Virgilio Dávila , poet
- Caridad De La Luz "La Bruja", poet, writer/actor of "Boogie Rican Blvd"
- Mayra Santos Febres , poet
- Dr. Rosario Ferré , writer
- Dr. Manuel Zeno Gandía , wrote "La Charca", the first Puerto Rican novel
- Alejandrina Benitez De Gautier , poet
- Enrique A. Laguerre , writer, nominated for Nobel Prize in literature
- Georgina Lázaro , children's poet
- Luis Palés Matos , poet of Afro-Caribbean themes
- René Marqués , playwright
- Dr. Concha Melendez , poet, writer
- Manuel Mendez Ballester , writer
- Mercedes Negron Muñoz , " Clara Lair ", poet
- Dr. Antonio S. Pedreira , writer and educator
- Pedro Pietri , poet,playwright, co-founder of the Nuyorican Poets Cafe
- Miguel Piñero , playwright, writer, co-founder of the Nuyorican Poets Cafe
- Luis Rafael Sanchez ,playwright
- Dr. Wilfredo Santa Gomez ,self help books author
- Esmeralda Santiago , author
- Alejandro Tapia Y Rivera , writer and poet, "The Father of Puerto Rican Literature"
- José Rivera , playwright, first Puerto Rican nominated for an "Oscar" in "Best Adopted Screenplay" category
- Dr. Juan M. Rivera, poet, essayist
- Lola Rodríguez De Tió , poet, wrote lyrics to the revolutionary "Borinqueña"
- Salvador Tió , (Poet, Humorist, Writer and inventor of the word "Espanglish")
- Elsa Tió , (Poet)
- Piri Thomas , writer, poet
- Edwin Torres , " Nuyorican Movement " poet
- Judge Edwin Torres , writer ('' Carlito's Way ''), New York Supreme Court Justice
- Luis Llorens Torres , poet
- Clemente Soto Vélez , poet and activist
- William Carlos Williams (Puerto Rican on his mother's side), Modernist poet.
- Deborah Carthy-Deu , Miss Universe 1985
- Susie Castillo , Miss USA 2003 (mother is Puerto Rican)
- Miriam Gonzalez , Playmate of the Month, March 2001
- Marisol Malaret , first Puerto Rican Miss Universe, 1970
- Marisol Maldonado , fashion model
- Wilnelia Merced , Miss World, 1975
- Astrid Muñoz , supermodel
- Cynthia Olavarria , Miss Puerto Rico 2005
- Denise Quiñones , Miss Universe 2001
- Chay Santini , supermodel
- Taina , model
- Dayanara Torres , Miss Universe 1993
- Gloria Velez , supermodel
- Carlota Alfaro , fashion
- Aida Alvarez , first Hispanic woman and the first Puerto Rican to hold a position in a President's Cabinet
- Luis Antonio , fashion
- Luisa Capetillo , labor leader
- Richard Carrion , Chairman of the Board Banco Popular , chairman International Olympic Committee 's Finance Committee
- Ramiro L. Colon , first administrator of Cooperativa de Cafeteros de Puerto Rico, ''Café Rico'' (official coffee of the Vatican )
- Atilano Cordero Badillo , Supermercados Grande
- Maria Vizcarrondo-De Soto , first Puerto Rican President and CEO of United Way of Essex and West Hudson
- Oscar De La Renta , fashion designer (Father was Puerto Rican)
- Fernando Fernandez , " Ron Del Barrilito " and "Alcoholado Santa Ana"
- Luis A. Ferré , Ponce Cement (see also )
- José Juan García , "CheJuan", founder of Hogares Crea
- Ramon Lopez Irizarry , inventor of Coco Lopez
- Gildo Massó , founder of Massó Enterprises and Casa's Massó
- Sandra Miranda , founder of Miranda Salon, Inc. & Miranda the Style Lounge
- Angel Munoz , founder of the Cyberathlete Professional League - widely regarded as the father of Esports
- Antonio Muñoz , sports promoter respoonsible for MLB and World Baseball Classic games in Puerto Rico
- Lisette Nieves , founder of "ATREVETE"
- Samuel A. Ramirez, Sr. , President and founder of "Ramirez & Co.", the largest Hispanic investment banking firm in Wall Street
- Angel Ramos , founder of Telemundo television network
- Miguel Ruíz , founder of Café Yaucono'
- Herb Scannell , Former Chairman of MTV Networks and president of Nickelodeon Networks
- Juan Serralles , founder of " Don Q " rum
- Joseph A. Unanue , president and CEO of Goya Foods , son of founder
- Salvador Vassallo , founder of Vassallo Industries Inc. (Industrias Vassallo Inc.), Vassallo Distribution Center, and Vassallo Molding Corp.
- Juan F. Acosta , composer of folklore music
- Johnny Albino , singer
- Natalie And Nicole Albino , " Nina Sky " hip hop
- Rafael Alers , danza composer, "first" Puerto Rican to compose a Hollywood musical score
- Tite Curet Alonso , salsa composer El Periódico De Ayer and Las Caras Lindas
- Marc Anthony , singer
- Chucho Avellanet , singer
- Lloyd Banks , (Puerto Rican on his mother's side), rapper
- Ray Barretto , salsa singer, jazz and salsa musician
- Eddie Benitez , Guitarist, song writer, Considered the Most sensual guitarist
- John Benitez , "Jellybean Benitez", music producer and remixer
- Lucecita Benítez , singer
- Obie Bermudez ,singer
- Americo Boschetti , singer and composer
- Roy Brown , folklore singer, composer
- Antonio Caban Vale "El Topo", folklore singer, composer
- Tego Calderón , reggaeton singer
- Juan Morel Campos , composer of Danzas
- Bobby Capo , singer, composer
- Vicente Carattini , singer and composer of Puerto Rican Christmas themes
- Nydia Caro , singer
- Pablo Casals , (Puerto Rican on his mother's side), cellist and composer
- Kevin Ceballo , Salsa singer
- Rafael Cepeda , composer, "The Patriarch of the Bomba and Plena"
- Iris Chacón , singer and vedette
- Chayanne , singer
- Jose Miguel Class , "El Gallito de Manati", singer
- Elvis Crespo , merengue singer
- Tony Croatto , singer/composer of Puerto Rican folk songs
- Bobby Cruz ,salsa singer
- Willie Colón , salsa singer
- Braulio Dueño Colón , composer of "Canciones Escolares"
- Cesar Concepcion , salsa singer
- Federico A. Cordero , composer and classical guitarist
- Millie Corretjer ,singer
- Rafael Cortijo ,salsa singer
- Joe Cuba ,bandleader, considered to be "The Father of the Boogaloo"
- Daddy Yankee ,reggaeton singer
- Pedro Ortiz Davila , "Davilita", Bolero singer
- Justino Díaz , opera singer
- Dr. Rafael Jose Diaz , "Rafael Jose", singer and television host
- Carmen Delia Dipini , singer
- Howie Dorough , singer, member of the Backstreet Boys
- Johnathan Dwayne , singer, composer
- Rafi Escudero , salsa singer
- Noel Estrada , composer of " En Mi Viejo San Juan "
- Cano Estremera ,singer, composer and poet
- Fat Joe , rapper
- Rene Farrait , former member of " Menudo "
- Cheo Feliciano ,singer
- José Feliciano , singer, composed " Feliz Navidad "
- Ruth Fernandez , singer
- Narciso Figueroa , "Father of the Modern Danza"
- Pedro Flores , composer
- Luis Fonsi , singer
- Angelo Garcia ,former member of " Menudo "
- Glory , Reggaeton singer
- Odilio Gonzalez , singer
- Oscar Hernandez , salsa musician (composer of Sex And The City theme song)
- Rafael Hernandez , Composer of " Preciosa " and " Lamento Borincano "
- Giovanni Hidalgo , percussionist
- Marta Casals Istomin , cellist, former President of Manhattan School Of Music , widow of musicians Pablo Casals and Eugene Istomin
- Rafael Ithier , founder of " El Gran Combo " orchestra
- La India ,salsa singer, known as the "Princess of Salsa"
- Carmita Jimenez , singer (known also as "La Dama de la Canción")
- George Lamond , pop/salsa singer
- Tito Lara , singer
- Héctor Lavoe , salsa singer
- Raphy Leavitt , composer, director and founder of "''La Selecta''"
- Jennifer López , singer and actress
- Johnny Lozada , former member of " Menudo "
- Papo Lucca , Lead Pianist of " La Sonora Ponceña "
- Lunna , singer
- Victor Manuelle , singer
- Ricky Martin , singer former member of "Menudo"
- Angie Martinez , Radio personality/rapper
- Charlie Masso , former member of "Menudo"
- Maxwell (musician) , R&B/Neo-Soul singer (father was Puerto Rican)
- Lisette Melendez , freestyle/latin-pop singer
- Ricky Melendez , former member of "Menudo"
- Luis Miguel ,singer born in Puerto Rico
- Ismael Miranda , "El Niño Bonito de la Salsa", singer and composer
- Angel Mislan , composer of Danzas
- Yolandita Monge , singer
- Andy Montañez , salsa singer
- Glenn Monroig ,composer, singer, sang the "first" Rap song in Spanish
- Gilberto Monroig , bolero singer
- Florencio Morales Ramos , "Ramito", folklore singer
- Ednita Nazario , singer
- Joe Negroni , Rock and Roll Hall of Famer, member of the Teenagers
- Tito Nieves , salsa singer
- Tommy Olivencia , salsa singer
- Don Omar reggaeton singer
- Tony Orlando (Puerto Rican on father's side), singer
- Choco Orta , female,salsa, singer
- Jeannie Ortega , R&B/reggaeton singer
- Luis "Perico" Ortiz , salsa singer, musician, composer, musical arranger and producer
- Shalim Ortiz , singer
- Eddie Palmieri , bandleader (won 7 Grammy Award s)
- Charlie Palmieri , pianist, bandleader
- Antonio Paolí , opera singer, first person in history to record an entire opera
- José Enrique Pedreira , Danza composer
- Angel "Cuco" Peña , musician, composer and producer
- Carlos Ponce , singer
- Tito Puente , musician, composer and producer
- Ivy Queen , rapper, known as "The Queen of Reggaeton"
- Luciano Quiñones , danza composer
- Ismael Quintana , salsa singer
- Jose Ignacio Quinton , pianist/composer of danzas
- Richie Ray , singer, composer, known as "The King of Salsa"
- Sylvia Rexach , singer, composer
- Danny Rivera , singer
- Jerry Rivera , salsa singer
- Dr. Graciela Rivera , opera singer
- Ismael Rivera , "El Sonero Mayor", salsa singer
- Roberto Roena , Band Leader of Apollo Sound Orchestra, Bongoes and percussion, dancer
- Felipe Rodriguez , "La Voz", Bolero singer
- Julito Rodriguez , singer
- Omar Rodriguez-Lopez , guitarist from The Mars Volta
- Pellin Rodriguez , salsa singer
- Tito Rodriguez , singer
- Kelis Rogers , (mother is Chinese Puerto Rican ), singer and television host
- Tito Rojas , "El Gallo"
- Robby Rosa , former member of " Menudo "
- Willie Rosario , composer, bandleader
- Felipe Rose , the Indian from The Village People , singer
- Julita Ross , singer of Danzas
- Frankie Ruiz , salsa singer
- Fernando And Nefty Sallaberry , former members of " Menudo "
- Claudio Sanchez , lead singer, lyricist and guitarist of Coheed And Cambria
- Jesús María Sanromá , the first person ever to be named official pianist of the Boston Symphony Orchestra
- Gilberto Santa Rosa , salsa singer
- Eddie Santiago , salsa singer
- Herman Santiago , rock n roll singer, composed song " Why Do Fools Fall In Love "
- Marvin Santiago , salsa singer
- Dr. Zoraida Santiago , singer and composer
- Daniel Santos , composer, singer of Bolero s
- Nino Segarra , salsa singer
- Xavier Serbia , former member of " Menudo "
- Banchy Serrano , singer, member of " Grupo Mania "
- Myrta Silva , singer, composer
- Arturo Somohano ,composer, Symphony orchestra conductor
- Brenda K. Starr ,singer (Puerto Rican on mother's side)
- Michael Stuart , singer
- Olga Tañon , singer, composer, (4 Grammys )
- Manuel Gregorio Tavarez , composer known as "The Father of the Puerto Rican Danzas"
- Gerardo Teissonniere , classical pianist and teacher
- Roberto Tirado , Spanish Harlem vocalist
- Ray Toro , Lead guitarist for My Chemical Romance
- Yolanda Vadiz , Gospel singer
- Bobby Valentin ,musician/bandleader
- Alan Vega , rock singer, of Suicide
- Tony Vega , Salsa singer
- Lisa Velez , singer, of Lisa Lisa And The Cult Jam
- Vico C , rapper
- Wilkins , singer and composer
- Joseph M. Acaba , educator, first Puerto Rican astronaut
- Dr. Ricardo Alegria , Anthropologist , Archaeologist , educator
- Dr. Pilar Barbosa , UPR prof, author and first modern-day Official Historian of Puerto Rico
- Dr. Jaime Benitez , longest serving chamcellor and president of the University Of Puerto Rico
- Anthony M. Busquets , electronic engineer, aero-space technologist
- Judge José A. Cabranes ,educator, first Puerto Rican to serve as a U.S. Circuit Court judge in the federal court in the continental United States.
- Dr. María Cadilla , educator, Women rights activist
- Dr. Jose Ferrer Canales , educator, writer and activist
- Dr. Pedro Valle Carlo , educator, environmentalist
- Miguel Alvarez Chico , electronic engineer, aero-space technologist
- Dr. Nitza Margarita Cintron ,scientist, Chief of NASA 's (JSC) Space and Health Care Systems Office
- Rafael Cordero ,educator beatified in 2004 by Pope John Paul II
- Juan R. Correa-Pérez, Ph.D. ,scientist, clinical andrologist and embryologist
- Dr. Orlando Figueroa , mechanical engineer, Director of Mars Exploration in NASA
- Nilita Vientos Gaston , educator, defended the use of Spanish in the courts of Puerto Rico
- Olga D. Gonzalez , NASA engineer, Member of Ohio's Women Hall of Fame
- Dr. Sixto Gonzalez , scientist, first Puerto Rican Director of the Arecibo Observatory
- Lucas G. Hortas , aero-space engineer, aero-space technologist
- Dr. Carlos A. Liceaga , electronic engineer, aero-space technologist
- Dr. Norman Maldonado , physician and fmr UPR president
- Debbie Martinez , computer engineer, aero-space technologist
- Lissette Martinez , electronic engineer, rocket scientist
- Dr. Concha Melendez , educator, writer poet
- Ana G. Mendez , educator, founder of the Ana G. Mendez University System
- Eugenio Maria De Hostos (see also )
- Ana María O'Neill , educator and women's rights advocate
- Dr. Carlos Ortiz Longo , mechanical engineer, Chief of Crew Health Care Systems and Exercise Countermeasures in NASA
- Lourdes Pamela Pop ,educator
- Dr. Antonia Pantoja , awarded the Presidential Medal Of Freedom
- Efrén Pérez Rivera , educator, environmentalist and founder of Caborrojeños Pro Salud Y Ambiente .
- Maria Luisa Penne , educator, painter
- Dr. Angel Ramos , Superintendent of the Sequoia Schools for the Deaf and Hard of Hearing
- Miguel Rodríguez , mechanical engineer, Chief of the Integration Office of the Cape Canaveral Spaceport Management Office
- Dr. Pedro Rodriguez , inventor, mechanical engineer
- Monserrate Roman , scientist, microbiologist
- Ana Roque , educator and suffragist
- Dr. Agustin Stahl , scientist
- Arturo Alfonso Schomburg , pioneer in black history
- Dr. Felix Soto Toro , electrical engineer, astronaut applicant
- Dr. Fernando E. Rodriguez Vargas , dentist, scientist, discovered the bacteria which causes dental cavity
- Dr. Margot Arce De Vázquez , educator, founder of the Department of Hispanic Studies in the University of Puerto Rico
- Anibal Acevedo Vila , 8th elected governor of Puerto Rico
- Sila María Calderón , first female and 7th elected governor of Puerto Rico
- Luis A. Ferré , 3rd elected governor of Puerto Rico (see also )
- Rafael Hernández Colón , 4th elected governor of Puerto Rico
- Luis Muñoz Marin , 1st elected governor of Puerto Rico
- Jesus T. Piñero , first Puerto Rican to be named Governor by the U.S.
- Juan Ponce De Leon II , first Puerto Rican to be temporary governor
- Carlos Romero Barcelo , 5th elected governor of Puerto Rico
- Dr. Pedro Rosello , 6th elected governor of Puerto Rico
- Roberto Sánchez Vilella , 2nd elected governor of Puerto Rico
- Jose Julian Acosta , journalist
- María Celeste Arraras , anchor for "Al Rojo Vivo"
- Barbara Bermudo , journalist, co-host of Univision s "Primer Impacto"
- Rafael Bracero , newscaster for " Noticentro 4 "
- Alicia Colon , Columnist for The New York Sun
- Christopher Crommett , Atlanta-based Exec VP CNN en Español
- Tomas De Jesus Mangual , journalist for "El Vocero"
- Carmen Dominicci , journalist, co-host of Univision s "Primer Impacto"
- Manuel Fernandez Juncos , journalist, wrote lyrics to " La Borinqueña "
- Jackie Guerrido , journalist and meteorologist for Univision s "Despierta America"
- Anibal Gonzalez Irizarry , former newscaster for "Telenoticias en accion"
- Carmen Jovet , journalist, first Puerto Rican woman named news anchor in Puerto Rico
- Michele LaFountain , anchor for the Spanish version of ESPN Sports Center
- Lynda Lopez , anchor for "WCBS" Ch2.
- Luis Francisco Ojeda , journalist, political critic for "WAPA T.V."
- Geraldo Rivera , journalist
- Edna Schmidt , anchor for "Telefutura"
- Ray Suarez , Senior Correspondent on the "News Hour with Jim Leher", former host of NPR's "Talk Of The Nation"
- Guillermo José Torres , newscaster for " Noticentro 4 "
- Elizabeth Vargas , co-anchor ABC World News Tonight
- Luz Nereida Velez , newscaster for " Noticentro 4 "
- PFC Domingo Arroyo , USMC, first Puerto Rican and U.S. serviceman to die during the Somalian Civil War
- Vice Admiral, Dr. Richard Carmona , U.S. Surgeon General under President George W. Bush
- Brigadier General Antonio Rodriguez Balinas , U.S. Army
- Brigadier General Antonio Valero De Bernabe , fought alongside Simón Bolívar
- Staff Sgt. Modesto Cartagena , U.S. Army, most decorated Hispanic in history
- Lieutenant General Pedro Del Valle , U.S. Marine Corps, first Hispanic three-star Marine general
- Rear Admiral Dr. Alberto Diaz, Jr. , U.S. Navy, first Hispanic Director of the San Diego Naval Medical District
- 1 Lt. Carmen Durnier , WAC's, one of the first Puerto Rican women Army officers
- Capt. Miguel Enriquez , Spanish naval captain, pirate, defeated the British in Vieques
- Major General Luis R. Esteves , U.S. Army, organized the Puerto Rican National Guard
- Major General Salvador E. Felices , U.S. Air Force, first Puerto Rican general in the U.S. Air Force
- CWO3 Rose Franco , USMC, first Hispanic woman Chief Warrant Officer in the Marine Corps
- PFC Fernando Luis Garcia , USMC, first Puerto Rican awarded the Medal Of Honor
- Major General Orlando Llenza , U.S. Air Force
- PFC Carlos Lozada , U.S. Army, awarded Medal of Honor
- Lt. Francisco Gonzalo Marin , Cuban Liberation Army, fought alondside Jose Marti
- Col. Teofilo Marxuach , U.S. Army, fired the first shot in World War I on behalf of the United States
- Capt. Angel Rivero Mendez , Spanish Army, fired the first shot against the Americans in the Spanish-American War in Puerto Rico, invented the "Kola Champange"
- Major General William A. Navas, Jr. , U.S. Army, first Puerto Rican named Assistant Secretary of the Navy
- Brigadier General Luis Padial , Spanish Army, played an essential role in the abolishment of slavery in Puerto Rico
- Admiral Ramon Power Y Giralt , Spanish Navy
- Col. Carlos Betances Ramirez , U.S. Army, first Puerto Rican to command a battalion in the Korean War
- Capt. Antonio De Los Reyes Correa , Spanish Army, defeated the British in Arecibo
- Major Fernando L. Ribas-Dominicci , U.S. Air Force, perished in Operation El Dorado Canyon
- Rear Admiral Frederick Lois Riefkohl , U.S. Navy
- General Juan Rius Rivera , Commander-in-Chief of the Cuban Liberation Army
- Capt. Manuel Rivera , USMC, First Puerto Rican and U.S. servicemen to die in Operation Desert Shield
- Admiral Horacio Rivero , U.S. Navy, first Hispanic four-star admiral
- SPC Lizbeth Robles , U.S. Army, first Puerto Rican female soldier born in Puerto Rico to die in Irak
- Master Sgt. Pedro Rodriguez , U.S. Army, awarded two Silver Stars in one week
- Captain Euripides Rubio , U.S. Army, awarded Medal of Honor
- Sp4c Hector Santiago-Colon , U.S. Army, awarded Medal of Honor
- MGySgt. Frankie Segarra , USMC, First Hispanic to reach the grade of Master Gunnery Sergeant in the Marine Corps
- SPC Frances M. Vega , U.S. Army, first Puerto Rican female soldier born in the U.S. to die in a war
- 2Lt. Juan Alonso Zayas , Spanish Army, fought in the Battle of Baler, Philippines
- Alfonso Arana , painter, founder of the ''Fundación Alfonso Arana''.
- Jean-Michel Basquiat , painter (Puerto Rican mother)
- Tomas Batista , sculptor
- Angel Botello , painter and sculptor
- Jose Buscaglia Guillermety , sculptor
- José Campeche , painter
- Gerry Ruiz Cirino ,Puerto Rican contemporary artist/painter
- James De La Vega , mural artist
- Jan D'Esopo , painter and sculptor
- Elizam Escobar , painter
- Obed Gomez , contemporary artist known as the "Puerto Rican Picasso"
- Lorenzo Homar , graphic artist
- Antonio Martorell , painter
- Francisco Oller , painter
- Antonio Broccoli Porto , painter and sculptor from San Juan
- Julio Rosado Del Valle , Abstract expressionist
- Alberto Vadi , sculptor from Aguadilla
- Ernesto Ramos Antonini ,former president of the Camara of Representatives of Puerto Rico
- Carmen E. Arroyo first Puerto Rican woman elected to any state assembly in the United States
- Herman Badillo , first Puerto Rican to serve in U.S. Congress
- Joaquín Balaguer , president of Dominican Republic (Puerto Rican on his father's side)
- Dr. José Celso Barbosa , "The Father of Puerto Rico's Statehood Movement"
- Antonio R. Barcelo , founder of the Puerto Rican Liberal Party
- Angel O. Berrios , fmr mayor of Caguas
- Ruben Berrios-Martinez , president of the Puerto Rican Independence Party
- Dr. Ramon Emeterio Betances , main leader of the Grito De Lares revolution
- Juan Bosch , president of Dominican Republic (Puerto Rican on his mother's side)
- Mariana Bracetti , leader of the Lares Revolutionary Council
- Juan Marí Bras , founder of the Puerto Rican Socialist Party
- Mathias Brugman , leader of the Grito De Lares
- Dr. Pedro Albizu Campos , founder of the Nationalist Party
- Blanca Canales , nationalist who led the Jayuya revolt
- Adolfo Carrión Jr. , present Bronx borough president (2001-present)
- Roman Baldorioty De Castro , "The Father of Puerto Rico's Autonomy"
- Segundo Ruiz Belvis , leader of the Grito De Lares revolt
- Adam Clayton Powell IV , son of civil rights leader Adam Clayton Powell, Jr. and New York state assembly member
- Oscar Collazo , one of two nationalists who attempted to assassinate President Harry S. Truman
- Jose Coll Y Cuchi , founder of the Puerto Rican Nationalist Party
- Dr. Gilberto Concepcion De Gracia , founder of the Puerto Rican Independence Party
- Rafael "Churumba" Cordero Santiago , former mayor of Ponce
- Federico Degetau , the first resident commissioner to the United States
- Dr. Jose De Diego , "The Father of Puerto Rico's Independence Movement"
- Dr. Antonio Fernós-Isern , first Puerto Rican cardiologist and Resident Commissioner.
- Maurice Ferre , former mayor of Miami, Florida
- Fernando Ferrer , Bronx (New York City) borough president
- Luis Fortuño , current Resident Commissioner
- Dr. Olga Viscal Garriga , nationalist
- Miguel Hernandez Agosto , fmr Senate President, chair PDP Status Education Committee
- Eugenio Maria De Hostos , (see also )
- Santiago Iglesias , labor activist and Resident Commissioner to Washington
- Tito Kayak , activist
- Lolita Lebron , nationalist
- Margarita Lopez , New York City councilwoman/activist
- Olga A. Mendez , first Puerto Rican New York State Senator
- Ines Mendoza , first lady of Puerto Rico
- Francisco Ramirez Medina , President of the Republic of Ruerto Rico ( September 28 , 1868 ), during "El Grito De Lares " revolt
- Kenneth McClintock , President of the Puerto Rico Senate
- Teodoro Moscoso Jr. , architect of Operation Bootstrap , former U.S. Ambassador to Venezuela (1961-1964)
- Luis Muñoz Rivera , Resident Commissioner in Washington,D.C.
- Dr. Antonia Novello , U.S. Surgeon General under President George H. W. Bush
- Dr. Hernan Padilla , fmr Mayor of San Juan, founder Puerto Rican Renewal Party
- Eddie Perez , Mayor of Hartford , Connecticut
- Roberto Prats , Senator
- Francisco Mariano Quiñones , the first president of Puerto Rico's Cabinet
- Roberto Rexach Benitez , fmr Senate President, educator, current columnist for El Vocero newspaper
- Ramon Luis Rivera , former mayor of Bayamón
- Manuel Rojas , leader of the " Grito De Lares "
- Felisa Rincón De Gautier , first woman to be elected mayor of an American Capital city.
- Manuela Santiago Collazo , former mayor of Vieques (1985-2000)
- Maria De Lourdes Santiago , first female "PIP" member to be elected into the Puerto Rican Senate
- Jose Serrano , most senior Puerto Rican congressman
- Griselio Torresola , one of two nationalists who attempted to assassinate President Harry S. Truman
- Nydia Velazquez , first Puerto Rican congresswoman
- Roberto Vigoreaux , former show host, former senator
- Bishop David Andres Alvarez , Episcopal Diocese of Puerto Rico
- Luis Cardinal Aponte Martínez ,first Puerto Rican to become a cardinal
- Father Francisco Ayerra De Santa Maria , Puerto Rico's first poet
- Bishop Juan Alejo De Arizmendi , first Puerto Rican to become a bishop
- Rev. Yiye Avila , pentecostal leader
- Rev. Nicky Cruz , former gangster turned minister
- Sister Maria Dominguez , beatified in 2004 by Pope John Paul II
- Sor Isolina Ferre , Catholic nun awarded Presidential Medal Of Freedom
- Juanita García Peraza , "Mita", founder of "Mita" religion
- Archbishop Roberto Gonzalez Nieves , Catholic Diocese of San Juan
- Rev. Jorge Raschke , outspoken evangelist
- Carlos Manuel Rodríguez a.k.a. "St.Charlie", beatified by Pope John Paul II in 2001
- Teofilo Vargas Sein , "Aron", leader of "Mita" religion
- Father Diego De Torres Vargas , first to write about the history of Puerto Rico.
- Benjamin Agosto , Ice dancer and Olympic medalist, figure skating
- Roberto Alomar , baseball player
- Sandy Alomar, Jr. , baseball player
- Carmelo Anthony , basketball player, Denver Nuggets (Puerto Rican on his father's side)
- Carlos Arroyo , basketball player, Orlando Magic
- Wilfred Benitez , boxer, member of Boxing Hall of Fame
- Dr. David "Kike" Bernier , fencing, member of Puerto Rican National Fencing Team
- Hiram Bithorn , baseball player, first Puerto Rican in Major League Baseball
- Kristina Brandi , tennis player
- Ivan Calderon , baseball player
- Ivan Calderon , boxer
- Fernando J. Canales , swimmer, first Puerto Rican to reach the final Championships
- Hector 'Macho' Camacho , boxer
- Orlando 'Peruchin' Cepeda , baseball player, member of Baseball Hall of Fame
- Roberto Clemente , baseball player, member of Baseball Hall of Fame
- Abdiel Colberg , Only Hispanic pro-rollerblader
- Dr. Rebekah Colberg , "The Mother of Puerto Rican Women's Sports"
- Carlitos Colon , professional wrestler
- Carly Colon (Carlitos Colon Jr.), professional wrestler
- Angel Cordero Jr. , jockey, member of Jockey Hall of Fame
- Maritza Correia , first black Puerto Rican woman in U.S. Olympic Swmming Team
- Joe Cortez , boxing referee
- José Miguel Cotto , boxer
- Miguel Cotto , boxer
- Eva Cruz , volleyball player
- Jose "Cheo" Cruz , baseball player
- Christian Dalmau , BSN basketball player
- Raymond Dalmau , basketball player
- Esteban De Jesus , boxer
- Carlos "Sugar" De Leon , first boxer in history to win cruiserweight title twice
- Carlos Delgado , baseball player, New York Mets
- Ivelisse Echevarria , inducted into the International Softball Federation Hall of Fame (2003)
- Alfredo Escalera , boxer
- Sixto Escobar , boxer, member of Boxing Hall of Fame
- Angel "Cholo" Espada , boxer, fmr. champ
- Gigi Fernández , tennis player
- Lisa Fernandez , softball, Olympic gold medalist
- Enrique Figueroa , sailing
- Germán Figueroa (Apolo), professional wrestler
- Bold Forbes , thoroughbred champion
- Ruben Gomez , first Puerto Rican to pitch and win a World Series game.
- Wilfredo Gomez , boxer, member of Boxing Hall of Fame
- Jorge "Peco" Gonzalez , marathon runner
- Juan "Igor" Gonzalez , baseball player
- Ivonne Harrison , track and field athlete
- Reggie Jackson , baseball player, member of Baseball Hall of Fame (Puerto Rican on father's side)
- Butch Lee , basketball player, first Puerto Rican to play in the NBA
- Angelita Lind , track and field athlete
- Laura Daniela Lloreda , member of Mexican National Volleyball Team
- Javy Lopez , baseball player, Baltimore Orioles
- Mike Lowell , baseball player, Florida Marlins
- Felix Magath , first Puerto Rican (mother is German) to play in World Cup Soccer for Germany
- Glenn Martinez , football player
- Edgar Martinez , baseball player
- Alberto Mercado , Olympian boxer, the only American citizen in the 1980 Olympics
- Jerome Mincy , basketball player
- John John Molina , boxer
- Pedro Montañez , boxer
- Mario "Quijote" Morales , BSN basketball player
- Pedro Morales , wrestler, member of WWE Hall of Fame
- Jonny Moseley , skier, first Puerto Rican to belong to the U.S. Ski Team
- Emilio "Millito" Navarro , first Puerto Rican to play in the Negro Leagues
- Luis Olmo , first Puerto Rican to hit a home run in a World Series
- Carlos Ortiz , boxer, member of Boxing Hall of Fame
- Jose Ortiz , basketball player
- Luis Ortiz , boxer, first Puerto Rican to win an Olympic medal in boxing
- Raul Papaleo , Puerto Rican National Volleyball Team
- Ernesto Pastor , bullfighter
- Victor Pellot , a.k.a. "Vic Power", baseball player, second black Puerto Rican in Major League Baseball
- Jorge Posada , baseball player, New York Yankees
- Peter John Ramos , basketball player
- Ramon Ramos , basketball player
- German Rieckehoff , former president of Puerto Rican Olympic Committee
- Ramon Rivas , NBA and International basketball player
- Marco Rivera , football player, first Puerto Rican selected to Pro Bowl
- Ron Rivera , football player, first Puerto Rican in the National Football League
- Ivan "Pudge" Rodríguez , baseball player, Detroit Tigers
- Juan "Chi-Chi" Rodríguez , golfer, member of Golf Hall of Fame
- Ruben Rodríguez , basketball player
- Jose "King" Roman , boxer, first Puerto Rican to fight for the world heavyweight title
- Edwin "El Chapo" Rosario , member of International Boxing Hall of Fame (2006)
- John Ruíz , first Hispanic heavyweight boxing champion
- Alex Sanchez , boxer
- Daniel Santiago , basketball player
- O.J. Santiago , football player
- Samuel Serrano , boxer
- Julio Toro , basketball coach
- Georgie Torres , holds BSN scoring record
- José "Chegui" Torres , boxer, member of Boxing Hall of Fame
- Félix "Tito" Trinidad , boxer
- Jesse Vassallo , swimmer, member of International Swimming Hall of Fame
- Wilfredo Vazquez , boxer
- Savio Vega , former WWE wrestler
- Juan Evangelista Venegas , the first Puerto Rican to win an Olympic medal
- Ada Velez , the first Puerto Rican female boxer, to win a championship
- Mark Watring , equestrian
- Bernie Williams , baseball player, New York Yankees
- Agüeybaná , Taíno chief, "supreme cacique"
- Agüeybaná II , brother of Agueybaná
- Arasibo , cacique, area of Arecibo
- Caguax , cacique, area of Caguas
- Hayuya , cacique, area of Jayuya
- Jumacao , cacique, area of Humacao
- Orocobix , cacique, area of Orocovis
- Urayoán , cacique, area that presently spans between Añasco and Mayagüez , orders the drowning of Diego Salcedo
- Miguel Arteta , film/television director The Good Girl , TV series Six Feet Under
- Yiye Avila , Mr. Universe (see also )
- Wilo Benet , celebrity chef, owner of Payá and Pikayo restaurants.
- Clara Benitez , matriarch of the Benitez boxing family and socialite
- Félix Benítez , engineer who designed the Normandie Hotel .
- Felipe Birriel , "El Gigante de Carolina", was the tallest Puerto Rican
- David Blaine , illusionist/magician (Puerto Rican father)
- Rebecca Canchani , ''Prima Ballerina'' of the National Ballet Theater Of Puerto Rico
- Will Castro , Owner of Unique Autosports/ SPEEDTV Reality TV show ''"Unique Whips"''
- Roberto Cofresí , Puerto Rico's most famous pirate
- Jose R. Coleman-Davis Pagán , Architect
- Crazy Legs , breakdancer, president of Rock Steady Crew
- Edgardo Diaz , founder of Menudo
- Faith Evans , Hawaiian-Puerto Rican-first woman to be named U.S. Marshal.
- Funky Joe , famous island radio personality
- Ana García , ballerina, founder of Ballets De San Juan
- Juan Manuel García Passalacqua , politic commentator, lawyer
- Victor Manuel Gerena , allegedly stole $7 million from Wells Fargo
- Alejandro Gonzalez Malave , controversial undercover policeman
- Alfred D. Herger , television Host, psychologist
- Maria Elena Holly , widow of rock legend Buddy Holly
- Daisy Martinez , actress/television host of PBS network show ''"Daisy Cooks!"''
- Nicole Muniz , murdered teenager, famous after death
- Jose Padilla , alleged al-Qaeda terrorist
- Silverio Perez , show host, musician and author
- Jai Rodriguez , of TV show '' Queer Eye For The Straight Guy ''
- Anthony Romero First Hispanic and gay Executive Director of the ACLU
- David Sanes , whose death eventually led to the U.S. military leaving Vieques
- Sonia Sotomayor , first Puerto Rican woman to serve as a U.S. Circuit Court judge
- Pedro Toledo , Retired FBI senior agent and two times police superintendent
- Juan R. Torruella , first Puerto Rican to serve as Chief Judge of the First Circuit Ct of Appeals
- Ramona Trinidad Iglesias , was world's oldest woman
- Carmen Consuelo Vargas-Cerezo , first female Puerto Rican federal judge
- Alani Vasquez , "Lala Vazquez" Host MTV
- Holly Woodlawn , actress/1960's avant-garde artist
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