- Uniontown Locks and Dam at Uniontown, Kentucky
- Ferry at Uniontown
- Henderson Bridge - railroad at Henderson, Kentucky
- John James Audubon Bridge - US 41 at Evansville, Indiana
- Future I-69 Bridge
- Newburgh Locks and Dam at Newburgh, Indiana
- Glover Cary Bridge - Old US 231 at Owensboro, Kentucky
- William H. Natcher Bridge - US 231 at Rockport, Indiana
- Bob Cummings Lincoln Trail Bridge at Hawesville, Kentucky
- Cannelton Locks and Dam at Cannelton, Indiana
- Matthew E. Welsh Bridge - KY 79 / IN 135 at Brandenburg, Kentucky
- Sherman Minton Bridge - I-64 / US 150 at Louisville, Kentucky and New Albany, Indiana
- Kentucky and Indiana Bridge - Norfolk Southern railroad at Louisville and New Albany
- McAlpine Locks And Dam at Louisville and New Albany ( Falls Of The Ohio )
- Fourteenth Street Bridge - Louisville And Nashville Railroad at Louisville and Clarksville, Indiana
- George Rogers Clark Memorial Bridge - US 31 at Louisville and Clarksville
- John F. Kennedy Memorial Bridge - I-65 at Louisville and Jeffersonville
- Big Four Bridge - abandoned line of the Cleveland, Cincinnati, Chicago And St. Louis Railroad at Louisville and Jeffersonville
- East End Bridge (proposed) - I-265 at Utica, Indiana
- Milton-Madison Bridge - US 421 at Madison, Indiana
- Ghent-Vevay Ferry (closed) at Ghent, Kentucky and Vevay, Indiana
- Markland Dam Bridge - KY 1188 / IN 101 at Markland, Indiana
- Markland Locks and Dam at Markland
- Ferry at Warsaw, Kentucky
- Ferry at Aurora, Indiana
- Carroll C. Cropper Bridge - I-275 at Lawrenceburg, Indiana
- Anderson Ferry at Anderson Ferry, Ohio
- Cincinnati Southern Bridge - Cincinnati Southern Railway at Ludlow, Kentucky and Cincinnati, Ohio
- Brent Spence Bridge - I-71 / I-75 at Covington, Kentucky and Cincinnati
- Chesapeake And Ohio Railway Bridge at Covington and Cincinnati
- Clay Wade Bailey Bridge - US 25 / US 42 / US 127 at Covington and Cincinnati
- John A. Roebling Suspension Bridge - KY 17 at Covington and Cincinnati
- Taylor-Southgate Bridge - US 27 at Newport, Kentucky and Cincinnati
- Newport Southbank Bridge (known As The Purple People Bridge) - pedestrian-only at Newport and Cincinnati
- Daniel Carter Beard Bridge - I-471 at Newport and Cincinnati
- Combs-Hehl Bridge - I-275 at Highland Heights, Kentucky
- Captain Anthony Meldahl Locks and Dam at Willow Grove, Kentucky
- Boudes Ferry at Augusta, Kentucky
- William H. Harsha Bridge - US 62 / US 68 at Maysville, Kentucky
- Simon Kenton Memorial Bridge at Maysville, Kentucky and Aberdeen, Ohio
- Carl Perkins Bridge - US 23 at Portsmouth, Ohio
- U.S. Grant Bridge (closed) at Portsmouth
- Sciotoville Bridge - railroad at Sciotoville, Ohio
- Jesse Stuart Memorial Bridge - Greenup Locks and Dam at Lloyd, Kentucky
- Ironton-Russell Bridge at Russell, Kentucky and Ironton, Ohio
- Ben Williamson Memorial Bridge at Ashland, Kentucky
- Simeon Willis Memorial Bridge at Ashland
- Big Sandy River splits
- Bridge - railroad at Kenova, West Virginia
- Nick J. Rahall Bridge - US 52 at Huntington, West Virginia
- Robert C. Byrd Bridge - WV 527 / OH 152
- East End Bridge - WV 106 / OH 607
- Silver Memorial Bridge - US 35 at Henderson, West Virginia and Kanauga, Ohio
- Silver Bridge (collapsed 1967 ) at Point Pleasant, West Virginia and Kanauga
- Bridge - railroad at Point Pleasant and Kanauga
- Bridge - OH 833 at Mason, West Virginia and Middleport, Ohio
- Racine Locks and Dam at Racine, Ohio
- Ravenswood Bridge - US 33 at Ravenswood, West Virginia and Meigs County, Ohio
- Belleville Locks and Dam at Belleville, West Virginia
- Belpre-Parkersburg Bridge - US 50 at Parkersburg, West Virginia and Belpre, Ohio
- Bridge - railroad at Parkersburg and Belpre
- Memorial Bridge at Parkersburg and Belpre
- Muskingum River splits at Marietta, Ohio
- Williamstown Bridge - WV 14 / WV 31 at Williamstown, West Virginia and Marietta
- Marietta-Williamstown Interstate Bridge - I-77 at Williamstown and Marietta
- Willow Island Locks and Dam at Willow Island, West Virginia
- Carpenter Bridge - WV 807 / OH 807 at St. Marys, West Virginia and Newport, Ohio
- New Martinsville Bridge - WV 7 at New Martinsville, West Virginia and Hannibal, Ohio
- Hannibal Locks and Dam at Hannibal
- Bridge - OH 872 at Moundsville, West Virginia and Dilles Bottom, Ohio
- Bridge - railroad at Benwood, West Virginia and Bellaire, Ohio
- Bellaire Bridge (closed) at Benwood and Bellaire
- Bridge - I-470 at Wheeling, West Virginia and Bellaire
The next two bridges cross the main channel of the river, located entirely in West Virginia between Wheeling Island and Wheeling.
- Wheeling Suspension Bridge - WV 251 at Wheeling
- Fort Henry Bridge - I-70 at Wheeling
- Wheeling Railroad Bridge - abandoned railroad at Wheeling and Martins Ferry, Ohio
- Pike Island Locks and Dam at Yorkville, Ohio
- Wabash Bridge - Pittsburgh And West Virginia Railway at Deandale, Ohio
- Bridge - railroad at Steubenville, Ohio
- Market Street Bridge at Steubenville
- Steubenville Railroad Bridge at Steubenville
- Veterans Memorial Bridge - US 22 between Steubenville, Ohio and Weirton, West Virginia
- Fort Steuben Bridge between Steubenville, Ohio and Weirton, West Virginia
- New Cumberland Locks and Dam at New Cumberland, West Virginia
- Newell Bridge at Newell, West Virginia and East Liverpool, Ohio
- Bridge (removed) - railroad between Chester, West Virginia and East Liverpool, Ohio
- Jennings Randolph Memorial Bridge - US 30 between Chester, West Virginia and East Liverpool, Ohio
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